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Inflammatory pseudotumor following hematopoietic stem cell transplantation: a new case and review of the literature

Bone Marrow Transplantation volume 40, pages 915–918 (2007)Cite this article

Abstract

Inflammatory pseudotumor (IPT) is a rare tumor that occurs in various organs and tissues. The clinical picture varies from the more frequent benign lesions to the rare malignant tumors with distant metastases. IPT associated with hematopoietic stem cell transplantation (HSCT) is rarely reported. In this article, we review the reports of IPT after HSCT and describe the first case of bladder IPT. We also review the possible factors involved in the pathogenesis. IPT might be rare but it is a potentially serious complication of HSCT. It should be considered in patients with otherwise unexplained inflammatory symptoms or signs or with any mass lesion in the post-HSCT period. A knowledge of this entity and insistence on a definitive biopsy of mass lesions in the post-HSCT period can avoid unnecessary treatment such as radical surgery, chemotherapy or radiotherapy.

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References

  1. Coffin CM, Watterson J, Priest JR, Dehner LP . Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995; 19: 859–872.

    Article  CAS  PubMed  Google Scholar 

  2. Fangusaro J, Klopfenstein K, Groner J, Hammond S, Altura RA . Inflammatory myofibroblastic tumor following hematopoietic stem cell transplantation: report of two pediatric cases. Bone Marrow Transplant 2004; 33: 103–107.

    Article  CAS  PubMed  Google Scholar 

  3. Ogura K, Ikeda T, Kobayashi S, Torikai H, Sato K, Kimura F et al. Inflammatory pseudotumor of the kidney arising after unrelated bone marrow transplantation. Bone Marrow Transplant 2004; 34: 831–832.

    Article  CAS  PubMed  Google Scholar 

  4. Tsutsumi Y, Kanamori H, Kawamura T, Umehara S, Obara S, Ogura N et al. Inflammatory pseudotumor of the brain following hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35: 1123–1124.

    Article  CAS  PubMed  Google Scholar 

  5. Priebe-Richter C, Ivanyi P, Buer J, Langer F, Lotz J, Hertenstein B et al. Inflammatory pseudotumor of the lung following invasive aspergillosis in a patient with chronic graft-vs.-host disease. Eur J Haematol 2005; 75: 68–72.

    Article  PubMed  Google Scholar 

  6. Dishop MK, Warner BW, Dehner LP, Kriss VM, Greenwood MF, Geil JD et al. Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy. J Pediatr Hematol Oncol 2003; 25: 153–158.

    Article  PubMed  Google Scholar 

  7. Coffin CM, Humphrey PA, Dehner LP . Extrapulmonary inflammatory myofibroblastic tumor. Semin Diagn Pathol 1998; 15: 85–101.

    CAS  PubMed  Google Scholar 

  8. Morotti RA, Legman MD, Kerkar N, Pawel BR, Sanger WG, Coffin CM . Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung: case report and review of the literature. Pediatr Dev Pathol 2005; 8: 224–229.

    Article  PubMed  Google Scholar 

  9. Pungpapong S, Geiger XJ, Raimondo M . Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature. JOP 2004; 5: 360–367.

    PubMed  Google Scholar 

  10. Harik LR, Merino C, Coindre JM, Amin MB, Pedeutour F, Weiss SW . Pseudosarcomatous myofibroblastic proliferations of the bladder: a clinicopathologic study of 42 cases. Am J Surg Pathol 2006; 30: 787–794.

    Article  PubMed  Google Scholar 

  11. Jackman SV, Schulam PG, Schoenberg M . Pseudotumor of the bladder: a late complication of inguinal herniorrhaphy. Urology 1997; 50: 609–611.

    Article  CAS  PubMed  Google Scholar 

  12. Wanibuchi H, Iwata H, Washida H, Tozawa K, Yamada Y, Kang K et al. A case report of inflammatory pseudotumor of the urinary bladder. Osaka City Med J 1995; 41: 31–39.

    CAS  PubMed  Google Scholar 

  13. Serra J, Matias-Guiu X, Calabuig R, Garcia P, Sancho FJ, La Calle JP . Surgical gauze pseudotumor. Am J Surg 1988; 155: 235–237.

    Article  CAS  PubMed  Google Scholar 

  14. Tan KB, Thamboo TP, Raju GC . Xanthomatous pseudotumor. An unusual postchemotherapy phenomenon in breast cancer. Arch Pathol Lab Med 2003; 127: 739–741.

    PubMed  Google Scholar 

  15. Isobe H, Nishi Y, Fukutomi T, Iwamoto H, Nakamuta M, Sakai H et al. Inflammatory pseudotumor of the liver associated with acute myelomonocytic leukemia. Am J Gastroenterol 1991; 86: 238–240.

    CAS  PubMed  Google Scholar 

  16. Remberger K, Weiss M, Gokel JM, Landgraf R, Illner WD, Land W . Inflammatory pseudotumor of the pancreas with persistent hyper-insulinemia and hypoglycemia following long-term pancreatic transplantation. Verh Dtsch Ges Pathol 1987; 71: 328–332.

    CAS  PubMed  Google Scholar 

  17. Lykavieris P, Fabre M, Waguet J, Bernard O . Inflammatory pseudotumor after liver transplantation. J Pediatr Gastroenterol Nutr 2000; 31: 309–312.

    Article  CAS  PubMed  Google Scholar 

  18. Lykavieris P, Fabre M, Pariente D, Lezeau YM, Debray D . Clostridium difficile colitis associated with inflammatory pseudotumor in a liver transplant recipient. Pediatr Transplant 2003; 7: 76–79.

    Article  PubMed  Google Scholar 

  19. Oota S, Shibuya H, Hamagaki M, Yoshimura R, Iwaki H, Kojima M et al. Oral pseudotumor: benign polypoid masses following radiation therapy. Cancer 2003; 97: 1353–1357.

    Article  PubMed  Google Scholar 

  20. Fujimaki K, Maruta A, Yoshida M, Kodama F, Matsuzaki M, Fujisawa S et al. Immune reconstitution assessed during five years after allogeneic bone marrow transplantation. Bone Marrow Transplant 2001; 27: 1275–1281.

    Article  CAS  PubMed  Google Scholar 

  21. Sugita K, Soiffer RJ, Murray C, Schlossman SF, Ritz J, Morimoto C . The phenotype and reconstitution of immunoregulatory T cell subsets after T cell-depleted allogeneic and autologous bone marrow transplantation. Transplantation 1994; 57: 1465–1473.

    Article  CAS  PubMed  Google Scholar 

  22. Ades L, Guardiola P, Socie G . Second malignancies after allogeneic hematopoietic stem cell transplantation: new insight and current problems. Blood Rev 2002; 16: 135–146.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    G Bahat

  2. Division of Hematology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    S Kalayoglu-Besisik & D Sargin

  3. Department of Internal Medicine, Clinic of Nephrology, Haseki Education and Research Hospital, Istanbul, Turkey

    S Ozturk

  4. Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    I Kilicaslan

  5. Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    M Tunc

Authors
  1. G Bahat
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  2. S Kalayoglu-Besisik
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  3. S Ozturk
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  4. I Kilicaslan
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  5. M Tunc
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  6. D Sargin
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Correspondence to G Bahat.

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Bahat, G., Kalayoglu-Besisik, S., Ozturk, S. et al. Inflammatory pseudotumor following hematopoietic stem cell transplantation: a new case and review of the literature. Bone Marrow Transplant 40, 915–918 (2007). https://doi.org/10.1038/sj.bmt.1705784

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