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World Marrow Donor Association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks

Bone Marrow Transplantation volume 39, pages 737–741 (2007)Cite this article

Abstract

Since the advent of the European Marrow Donor Information System in the first half of the last decade, fully automated data exchange between registry computer systems has been playing an ever-increasing role in the international search for unrelated donors of blood progenitor cells. This exchange, however, was hampered by different local conventions used to present HLA data and complicated by the need to extend the official WHO nomenclature to accommodate the registries’ information systems and to cross-validate HLA data obtained with different methods and/or at different loci. The guidelines presented here have been developed by the World Marrow Donor Association to standardize the nomenclature to be used and the validation checks to be applied in the international electronic exchange of HLA-typing data among unrelated volunteer hematopoietic stem cell donor registries and umbilical cord blood banks. Two reference web sites have been designated to maintain and update the approved HLA nomenclature and all the ancillary information needed by the conventions described here.

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Acknowledgements

This has been a project of the Information Technology and Quality Assurance Working Groups of the WMDA. Working group members and the WMDA Board have provided valuable input to this document.

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Authors and Affiliations

  1. Information Technology and Quality Assurance Working Groups of the World Marrow Donor Association, Leiden, The Netherlands

    W Bochtler, M Maiers, M Oudshoorn, S G E Marsh, C Raffoux, C Mueller & C K Hurley

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  1. W Bochtler
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  2. M Maiers
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  3. M Oudshoorn
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  4. S G E Marsh
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  5. C Raffoux
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  6. C Mueller
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  7. C K Hurley
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Correspondence to C K Hurley.

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Bochtler, W., Maiers, M., Oudshoorn, M. et al. World Marrow Donor Association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks. Bone Marrow Transplant 39, 737–741 (2007). https://doi.org/10.1038/sj.bmt.1705672

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  • DOI: https://doi.org/10.1038/sj.bmt.1705672

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