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Cord Blood Stem Cells

Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect

Bone Marrow Transplantation volume 38, pages 729–732 (2006)Cite this article

Abstract

We report a 69-year-old man with cytokine-resistant metastatic renal cell carcinoma treated with reduced-intensity unrelated cord blood transplantation. The patient achieved durable donor engraftment with minimal graft-versus-host disease. The patient showed regression of metastatic disease, providing the first evidence of a graft-versus-tumor effect on a solid tumor resulting from cord blood graft.

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Acknowledgements

This work was supported in part by Grant-in-Aids for Scientific Research from the Ministry of Education, Science, Technology, Sports and Culture (KAKENHI 15790490) and from the Ministry of Health, Labor and Welfare, Japan. We are indebted to the patient and his family for participating in this study, to the staff at the Division of Hematology and Oncology at Kanazawa University Hospital, to the Japan Cord Blood Bank Network for processing the cord blood units, to Dr Richard Childs for valuable suggestions for the current study and to Megumi Yoshii and Arisa Hamano for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

    A Takami, H Takamatsu, H Yamazaki, K Ishiyama, H Okumura, K Ohata, H Asakura & S Nakao

  2. Department of Urology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

    H Konaka & M Namiki

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  1. A Takami
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Correspondence to A Takami.

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Takami, A., Takamatsu, H., Yamazaki, H. et al. Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect. Bone Marrow Transplant 38, 729–732 (2006). https://doi.org/10.1038/sj.bmt.1705519

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