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Graft-versus-Host Disease

Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods

Bone Marrow Transplantation volume 37, pages 955–959 (2006)Cite this article

Abstract

Salivary gland dysfunction is a common sequela of hematopoietic progenitor cell transplantation (HPCT). The investigation of major salivary gland dysfunction with sodium pertechnetate scintigraphy is a non-invasive method that provides images of the parotid and submandibular glands. In this prospective trial, 20 HPCT patients were submitted to scintigraphic study with 99mTc-pertechenate and 67Ga in order to evaluate the major salivary glands early involvement following HPCT. Major salivary glands were evaluated prior to HCPT as well as at Days +30, +60 and +100 post transplant. Major salivary glands uptake and clearance of 99mTc-pertechenate results did not demonstrate any functional differences between pre- versus post transplant periods. Results of the 67Ga scan revealed inflammatory infiltration following HPCT, primarily in submandibular glands, suggest a persistent involvement of major salivary glands up to Day +100 after HPCT.

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Acknowledgements

We gratefully acknowledge the support and contributions of the staff of the Nuclear Medicine Service of University Hospital – Campinas State University, HPCT Unit. The expert data management by Mrs Eliana Miranda and Mrs Amanda Margelo is also sincerely appreciated. This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo-FAPESP-(The State of São Paulo Research Foundation) proc. 00/12188-4.

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Authors and Affiliations

  1. BMT Unit, Hematology and Blood Transfusion Center (Hemocentro), State University of Campinas, São Paulo, Brazil

    F L Coracin, M E Pizzigatti Correa, A C Vigorito, G Borba Oliveira, K A de Brito Eid, R Zulli & C A De Souza

  2. Division of Nuclear Medicine, Department of Radiology, State University of Campinas, São Paulo, Brazil

    E E Camargo & A de Oliveira Santos

  3. Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, Head & Neck/Oral Oncology Program, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT, USA

    D E Peterson

Authors
  1. F L Coracin
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  2. M E Pizzigatti Correa
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  3. E E Camargo
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  4. D E Peterson
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  5. A de Oliveira Santos
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  9. R Zulli
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  10. C A De Souza
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Correspondence to C A De Souza.

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Coracin, F., Pizzigatti Correa, M., Camargo, E. et al. Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods. Bone Marrow Transplant 37, 955–959 (2006). https://doi.org/10.1038/sj.bmt.1705351

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