Summary:
The current study attempted to evaluate the association between the IL-10 promoter gene single nucleotide polymorphism (SNP) and invasive pulmonary aspergillosis (IPA) after allogeneic stem cell transplantation (SCT) in 105 patients. Three single-nucleotide polymorphisms were investigated in the proximal region of the IL-10 promoter gene (−1082/−819/−592). Two haplotypes (1082*A/819*T/592*A [ATA] and 1082*A/819*C/592*C [ACC]) were found in the current study. The overall incidence of IPA was estimated as 14.1±4.5% with a median onset at 186 days post-transplant (62∼405 days). An increased occurrence of IPA was noted dependent on the IL-10 haplotype (0% vs 11.5±6.4% vs 19.7±7.7% for ACC/ACC vs ATA/ACC vs ATA/ATA haplotype, P=0.0307 when comparing ACC with non-ACC haplotype). In a multivariate survival analysis using Cox's proportional hazard model, the IL-10 promoter gene SNPs were identified as an independent predictive factor for the development of IPA (P=0.012, hazard ratio (HR) 9.3), along with an histocompatibility leukocyte antigen (HLA)-identical donor (P=0.005, HR 16.3), the CD34+ cell dose transplanted (P=0.004, HR 26.5), and time-dependent chronic graft-versus-host disease (GVHD; P=0.049, HR 16.0). The IL-10 ACC haplotype was found to have an apparent protective role in the development of IPA after allogeneic transplantation, regardless of HLA-disparity or chronic GVHD.
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The great work of our nursing staff is gratefully acknowledged. This work was supported by a grant from the Advanced Medical Technology Cluster for Diagnosis and Prediction at KNU from the MOCIE, Republic of Korea (Advanced Medical Technology Cluster for Diagnosis and Prediction, School of Medicine, Kyungpook National University Dongin-dong 101, Daegu 700-422, South Korea; Tel: +82 53 420 4974, Fax: +82 53 421 4974).
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Seo, K., Kim, D., Sohn, S. et al. Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation. Bone Marrow Transplant 36, 1089–1095 (2005). https://doi.org/10.1038/sj.bmt.1705181
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DOI: https://doi.org/10.1038/sj.bmt.1705181
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