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Allografting

The implication of follicular lymphoma patients receiving allogeneic stem cell transplantation from donors carrying t(14;18)-positive cells

Bone Marrow Transplantation volume 35, pages 1049–1054 (2005)Cite this article

Summary:

We performed real-time quantitative polymerase chain reaction (RQ-PCR) in peripheral blood (PB) and/or bone marrow (BM) samples collected pre- and post transplant from 23 recipient–donor pairs receiving allogeneic stem cell transplantation (allo-SCT) for follicular lymphoma (FL). Of 23 donors, 11 had a PB and/or BM sample positive for t(14;18) (BCL2/IGH fusion) at low levels (<one t(14;18) cell in 10K total cells). Recipients from donors with (n=11) and those without (n=12) detectable t(14:18) cells were similar in age, sex, and disease status pretransplant. No differences in the incidence of graft-versus-host-disease (GVHD), delayed engraftment, relapse rate, disease-free survival and overall survival were identified between the groups. Two recipients without detectable t(14;18) cells pre-transplant showed detectable t(14;18) cells at 2 and 11 years after receiving grafts from donors with t(14:18) cells. Neither patient developed FL 1.5 and 2 years after the emergence of t(14;18) cells. Although the sample size is relatively small, our findings suggest that individuals carrying t(14;18) cells may not be excluded as donors given the lack of an association of t(14;18) detected in donors with adverse clinical outcome. It may be necessary to screen for the donor's t(14;18) status before using t(14;18) for monitoring minimal residual disease by RQ-PCR to exclude the possibility of confounding donor's t(14;18) clone.

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Authors and Affiliations

  1. Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, TX, USA

    D K McGregor

  2. Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA

    C A Keever-Taylor, C Bredeson & D H Vesole

  3. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA

    B Schur

  4. Department of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA

    B Logan

  5. Department of Pathology, The Methodist Hospital, Weil Medical College, Cornell University, Houston, TX, USA

    C-C Chang

Authors
  1. D K McGregor
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  2. C A Keever-Taylor
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  3. C Bredeson
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  4. B Schur
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  5. D H Vesole
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  6. B Logan
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  7. C-C Chang
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Correspondence to C-C Chang.

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McGregor, D., Keever-Taylor, C., Bredeson, C. et al. The implication of follicular lymphoma patients receiving allogeneic stem cell transplantation from donors carrying t(14;18)-positive cells. Bone Marrow Transplant 35, 1049–1054 (2005). https://doi.org/10.1038/sj.bmt.1704969

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