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Update on extracorporeal photochemotherapy for graft-versus-host disease treatment

Bone Marrow Transplantation volume 35, pages S69–S71 (2005)Cite this article

Summary:

Pediatric experience with extracorporeal photochemotherapy (ECP) for graft-versus-host disease (GvHD) has mainly been reported by Italian and French groups. Data concerning 41 children with acute GvHD and 63 children affected by chronic GvHD are available. In 73 and 63% of them, respectively, improvement was observed, with addition of ECP to their immunosuppressive regimen. Treatment with ECP was associated with minimal side effects, even in the smallest of patients. In all responded pediatric patients, both with acute and chronic GvHD, ECP allowed progressive reduction or discontinuation of the concomitant pharmacological immunosuppressive therapy without an increase in GvHD acitivity. These data show that ECP is a useful therapy for children affected by GvHD resistant to conventional treatment and can be safely used.

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Authors and Affiliations

  1. Unité Bioclinique de Thérapie Cellulaire, C.H.U. Clermont-Ferrand, France

    J Kanold, P Halle & F Deméocq

  2. Pediatric hematology and oncologic Unity, University of Padua, Italy

    C Messina & S Cesaro

  3. IRCCS Policlinico S Matteo, Pavia, Italy

    F Locatelli

  4. IRCCSG, Gaslini, Genova, Italy

    E Lanino

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  1. J Kanold
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  2. C Messina
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  4. F Locatelli
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  5. E Lanino
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  6. S Cesaro
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  7. F Deméocq
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on behalf of the Paediatric Diseases Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

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Correspondence to J Kanold.

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Kanold, J., Messina, C., Halle, P. et al. Update on extracorporeal photochemotherapy for graft-versus-host disease treatment. Bone Marrow Transplant 35 (Suppl 1), S69–S71 (2005). https://doi.org/10.1038/sj.bmt.1704851

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