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Survey on haematopoietic stem cell transplantation for children in Europe

Bone Marrow Transplantation volume 35, pages S3–S8 (2005)Cite this article

Abstract

Summary:

A recent report, prepared in March 2003, regarding the paediatric transplantation activity registered between 1970 and 2002 in the European Bone Marrow Transplantation (EBMT) database showed a decrease in the number of registrations in 2001 and in 2002. In order to validate this observation, the Paediatric Diseases Working Party (PDsWP) secretariat distributed a questionnaire to 395 institutions participating in the EBMT Registry. Each institution was requested to check the number of transplants they reported and to confirm or to correct the figures. As of 15 March 2004, replies had been received from 135 centres reporting a median of 48 transplants per centre over the study period, total 17 891 (58% of the total number). Among them, 55 confirmed their original figures, while 80 corrected the numbers. The overall number of autologous and allogeneic SCTs performed and not reported were 461 and 692, respectively. Most of the teams that corrected their figures stated that their data managers could provide missing data to the EBMT; 260 other teams, each reporting a median of 15 transplants during the study period, total 12 866 (42% of the total number) chose not to reply. A report prepared in March 2004, following the PDsWP survey, showed an increasing number of transplants performed on patients below 18 years of age between 1973 and 2002 and reported to the EBMT Registry (328 autologous and 628 allogeneic) as compared to the 2003 report. This first PDsWP survey, reaching more than 50% of activity in the field, illustrates that the decrease in activity we observed in the 2003 report does not correspond to a decrease in the number of transplants that were actually performed. It demonstrates the compliance of most major paediatric institutions and confirms the important role of cooperation between National Registries and EBMT Registries.

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Acknowledgements

We acknowledge all the participating teams and the EBMT Registry Subcommittee (C Ruiz de Elvira), the EBMT Acute Leukemia Registry (M Labopin), the Austrian Registry (HT Greinix, B Lindner,), the British Registry (J Apperley, K Towlson), the Czech Registry (M Trnkova, K Benesova), the Dutch Registry (A Hagenbeek, M Smeets), the Italian Paediatric (AIEOP) Registry (A Pession, R Rondelli) and the Swiss Registry (A Gratwohl, H Baldomero). This work was supported in part by a grant from CARIGE and the Compagnia San Paolo.

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Authors and Affiliations

  1. Department of Paediatric Haematology and Oncology, IRCCS ‘G Gaslini’, Genova, Italy

    M Miano & G Dini

  2. Paediatric Diseases Secretariat, IRCCS ‘G Gaslini’, Genova, Italy

    R Cancedda

  3. BMT Unit, Department of Paediatric Oncology, Institut Gustave Roussy, Villejuif, France

    O Hartmann

  4. Department of Paediatric Oncology/BMT, Bristol Royal Hospital for Children, Bristol, UK

    J Cornish

  5. Department of Paediatric Haematology-Oncology, IRCCS Policlinico San Matteo, Pavia, Italy

    F Locatelli

  6. Department of Paediatrics, University Hospital, Leiden, The Netherlands

    R M Egeler

  7. Department of Bone Marrow Transplantation, Hadassah University Hospital, Ein-Karem, Jerusalem, Israel

    S Slavin

  8. BMT Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK

    P Veys

  9. Department of Paediatric Haematology-Oncology, Hospital M Infantil Val d'Hebron, Barcelona, Spain

    J Ortega

  10. BMT Unit, St Anna Kinderspital, Wien, Austria

    C Peters

  11. Royal Manchester Children Hospital, Pendlebury, UK

    R F Wynn

  12. Department of Haematology, University La Sapienza, Roma, Italy

    A P Iori

  13. Department of Paediatrics, Ospedale Regina Margherita, Torino, Italy

    F Fagioli

  14. Department of Haematology, Huddinge University Hospital, Sweden

    P Ljungmann

  15. Department of Paediatrics, University Hospital, Tubingen, Germany

    D Niethammer

  16. Department of Paediatrics, Hopital d'Enfants, Vandeouvre Les Nancy, France

    P Bordigoni

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  1. M Miano
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  2. R Cancedda
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  3. O Hartmann
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  4. J Cornish
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  5. F Locatelli
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  6. R M Egeler
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  7. S Slavin
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  8. P Veys
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  9. J Ortega
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  10. C Peters
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  11. R F Wynn
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  12. A P Iori
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  13. F Fagioli
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  14. P Ljungmann
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  15. D Niethammer
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  17. G Dini
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Consortia

on behalf of the EBMT Paediatric Diseases Working Party

Corresponding author

Correspondence to G Dini.

Appendix

Appendix

List of transplant centres that had replied to the questionnaire. The number of allogeneic and autologous transplants reported between 1970 and December 2002 to the EBMT is listed first, followed by the number of allograft and autograft transplants that were actually performed.

*Paediatric centres; #combined centres in which children represented more than 25% of treated patients; °combined centres in which children represented less than 25% of treated patients.

Algeria (1 team; 106-6/106-6)

Alger, Centre Pierre et Marie Curie#, CIC 703, RM Hamladji, (106-6/106-6).

Australia (1 team; 16-0/24-22)

Randwick, Sydney Children's Hospital*, CIC 698, M Vowels, (16-0/24-22)

Austria (7 teams; 402-281/402-280)

Graz, University Children's Hospital*, CIC 593, C Urban (50-40/50-40); Innsbruck, University Hospital°, CIC 271, G Gastl (36-40/36-40); Linz, Elisabethinen-Hospital°, CIC 594, D Lutz (0-5/0-5); Wien, AKH und University°, CIC 227, H Greinix (6-4/6-4); Wien, St Anna Kinderspital*, CIC 528, H Gadner (310-189/310-188); Wien, Hanuschkrankenhaus°, CIC 743, E Koller (0-2/0-2); Wien, Wilhelminenspital°, CIC 828, L Heinz (0-1/0-1).

Belgium (3 teams; 41-30/42-33)

Antwerp, AZ Middelheim°, CIC 783, R Debock (0-4/0-4); Hasselt, Virga Jesse Hospital°, CIC 632 G Bries (0-2/0-2); Liege, University of Liege°, CIC 726, Y Beguin (41-24/42-27).

Czech Republic (1 team; 154-15/172-24)

Prague, University Hospital Motol*, CIC 656, J Stary (154-15/172-24).

Denmark (1 team; 295-56/299-44)

Copenhagen, Pediatric Clinic Rigshospitalet*, CIC 206, C Heilmann (295-56/299-44).

Finland (3 teams; 224-147/247-195)

Helsinki, Hospital for Children & Adolescents*, CIC 219, U Pihkala (205-137/225-177); Helsinki, Helsinki University Central Hospital°, CIC 833, R Janes (0-3/0-3); Turku, Turku University Central Hospital°, CIC 225, K Remes, (19-7/22-15).

France (9 teams; 643-1,719/713-1,703)

Clermont-Ferrand, Hotel Dieu CHU#, CIC 273, F Deméocq (102-243/108-193); Dijon, Hopital d'Enfants CHU de Dijon°, CIC 667, D Caillot (1-9/1-10); Lille, Centre Oscar Lambret#, CIC 972, AS Defachelles (0-52/0-52); Lyon, Hôpital Debrousse*, CIC 806, N Philippe (228-52/285-53); Paris, Hopital Cochin°, CIC 280, F Dreyfus (4-3/4-3); Paris; Hôpital Tenon°, CIC 747, JP Lotz (0-7/0-0); Strasbourg, Hopital de Hautepierre*, CIC 953, B Lioure (79-53/78-64); Vandoeuvre, Hopital d'Enfants*, CIC 676, P Bordigoni (216-161/218-135); Villejuif, Institut Gustave Roussy*, CIC 503, O Hartmann (13-1139/19-1193).

Germany (13 teams; 891-420/1,036-495)

Bremen, Klinikum Bremen-Mitte, CIC 602, CR Meier (0-5/0-5); Dusseldorf, Heinrich-Heine Universitat*, CIC 651, U Göbel (145-75/165-87); Giessen, Univ. Children's Hosp.*, CIC 326, A Reiter (7-4/17-9); Hamburg, University Hospital Eppendorf°, CIC 614, AR Zander (113-48/119-48); Ruprecht-Karls Universitats°, CIC 524, AM Geueke (1-21/1-13); Jena, Universitats-Kinderklinik*, CIC 750, F Zintl (130-87/212-148); Magdeburg, Fakultät Otto-von-Guericke°, CIC 359, M Koenigsmann (0-1/0-1); Munchen-Schwabing, Klinikum°, CIC 150, N Fischer (6-9/12-3); Rostock, Universität Klinikum°, CIC 585, M Freund (5-2/6-2); Stuttgart, Katharinen Hospital°, CIC 143, J Schleicher (0-3/0-3); Tubingen, University Hospital*, CIC 535, D Niethammer (254-154/263-166); Ulm, Universität Kinderklinik*, CIC 204, W Friedrich (228-10/228-10); Wiesbaden, KMT Zentrum°, CIC 311, R Schwerdtfeger (2-1/13-0).

Greece (1 team; 0-7/0-7)

Athens, Hellenic Cancer Institute St Savas Oncology Hospital°, CIC 751, A Efremidis (0-7/0-7).

Ireland (1 team; 70-1/69-1)

Dublin, St James Hospital Trinity College°, CIC 257, S McCann (70-1/69-1).

Israel (2 teams; 489-133/559-152)

Jerusalem, Hadassah University Hospital#, CIC 258, S Slavin (429-106/499-125); Tel Hashomer, Chaim Sheba Medical Center*, CIC 572, T Amos (60-27/60-27).

Italy (31 teams; 2537-2338/2481-2333)

Ancona, Az. Ospedale Umberto I°, CIC 788, P Leoni (2-21/0-28); Bologna, Università di Bologna*, CIC 790, A Pession (113-168/110-168); Brescia, Universitá di Brescia*, CIC 741, F Porta (187-41/187-40); Brescia, Spedali Civili°, CIC 288, G Rossi (6-5/6-2); Cagliari, Univ. of Cagliari Osp. per le Microcitemie*, CIC 812, F Argiolu (66-13/69-12); Cagliari, PO ‘R Binaghi’#, CIC 811, G Lanasa (47-1/47-1); Catania, Divisione Ematologia Pediatrica*, CIC 836, A Di Cataldo (13-20/13-20); Firenze, Azienda Ospedaliera Meyer*, CIC 600, L Faulkner (0-79/3-59); Firenze, Ospedale di Careggi°, CIC 304, A Bosi (25-13/24-12); Genova, Istituto G Gaslini*, CIC 274, G Dini (233-492/234-504); Genova, Ospedale S Martino°, CIC 217, A Bacigalupo (159-40/160-40); Latina, Ospedale S Maria Goretti°, CIC 379, A De Blasio (0-1/0-1); Milano, Istituto Nazionale per lo Studio e la Cura dei Tumori*, CIC 616, R Luksch (4-177/0-175); Modena, Università di Modena°, CIC 543, F Narni (1-5/1-5); Monza, Ospedale San Gerardo*, CIC 279, C Uderzo (248-51/244-56); Napoli, Ematologia Pediatrica Napoli*, CIC 341, M Ripaldi (22-22/22-21); Padova, Clinica di Oncoematologia Pediatrica*, CIC 285, C Messina (137-190/140-194); Pavia, IRCCS Policlinico San Matteo*, CIC 557, F Locatelli (498-173/502-179); Perugia, Silvestrini Hospital*, CIC 815, A Amici (17-35/23-39); Pescara, Ospedale Civile#, CIC 248, P Di Bartolomeo (198-30/134-5); Pisa, Università di Pisa*, CIC 795, C Favre (68-38/70-39); Ravenna, Ospedale Civile°, CIC 306, G Rosti (0-36/0-36); Roma, Università ‘La Sapienza’°, CIC 232, M Vignetti (183-199/183-199); Roma, Ospedale Bambino Gesú*, CIC 315, M Caniglia (19-11/19-12); Roma, Ospedale Bambino Gesù*, CIC 796, G Deb (0-107/0-110); Roma, Università Cattolica S Cuore°, CIC 307, G Leone (2-4/2-4); San Giovanni Rotondo, Ospedale Casa Sollievo della Sofferenza*, CIC 350, M Pastore (0-41/0-42); Torino, Ospedale Regina Margherita*, CIC 305, F Fagioli (153-223/143-233); Torino, Ospedale S Giovanni°, CIC 231, M Falda (7-21/7-21); Trieste, Istituto per l'Infanzia ‘Burlo Garofolo’*, CIC 525, M Andolina (122-68/131-68); Verona, Policlinico GB Rossi°, CIC 623, F Benedetti (7-13/7-8).

Netherlands (4 teams; 720-84/698-107)

Amsterdam, Free University Hospital°, CIC 588, GJ Ossenkoppele (1-2/2-3); Leiden, University Hospital*, CIC 203, RM Egeler (583-13/557-33) Nijmegen, St Radboud*, CIC 237, P Hoogerbrugge (49-45/49-45); Utrecht, University Hospital for Children*, CIC 239, M Bierings (87-24/90-26).

Poland (3 teams; 24-52/182-214)

Lublin, Children's University Hospital*, CIC 678, JR Kowalczyk (21-43/29-53); Warsaw, The Medical University of Warsaw°, CIC 954, W Wiktor-Jedrzejczak (2-1/1-1); Wroclaw, Wroclaw Medical University*, CIC 817, A Chybicka (1-8/152-160).

Portugal (1 team; 64-30/153-99)

Lisboa, Inst. Portugues Oncologia#, CIC 300, M Abecasis (64-30/153-99).

Romania (1 team; 1-0/0-1)

Bucharest, Fundeni University Institute°, CIC 296, C Arion (1-0/0-1).

Russia (2 teams; 31-47/58-56)

St Petersburg, Research Institute of Hematology°, CIC 724, KM Abdulkadirov (6-9/9-10); St Petersburg, Pavlov Medical University#, CIC 725, BV Afanassiev (25-38/49-46).

Slovakia (1 team; 22-25/22-25)

Bratislava, BMT Unit, Pediatric University Hospital*, CIC 684, J Lukac (22-25/22-25).

Slovenia (1 team; 14-8/16-10)

Ljubljana, University Medical Center°, CIC 640, J Pretnar (14-8/16-10).

Spain (13 teams; 725-1103/818-1147)

Barcelona, Hospital Santa Creu i Sant Pau*, CIC 260, I Badell-Serra (126-195/124-198); Barcelona, Hospital Vall d'Hebron*, CIC 527, J Ortega (234-275/322-303); Barcelona, Hospital Universitari Germans Trias i Pujol°, CIC 613, JM Ribera (0-3/0-3); Barcelona, Hospital Sant Joan de Deu*, CIC 668, J Estella (0-46/0-46); Madrid, Niño Jesus Children's Hospital*, CIC 732, M Diaz (103-216/103-216); Madrid, Hospital Infantil La Paz*, CIC 734, AM Martínez-Rubio (72-131/70-134); Madrid, Hospital Gregorio Marañón°, CIC 819, J Diez-Martin (8-11/9-10); Pamplona, Hospital de Navarra°, CIC 577, K Perez (0-7/0-7); Salamanca, Hospital Clínico°, CIC 727, D Caballero (12-15/12-15); Santander, Hospital U. Marqués de Valdecilla°, CIC 242, E Bureo (101-59/101-59); Valencia, Hospital Infantil La Fe*, CIC 653, V Castel (41-131/42-131); Valencia, Hospital Universitario La Fe*, CIC 663, M Sanz (28-12/35-23); Zaragoza, Hospital Clínico°, CIC 531, M Gutierrez (0-2/0-2).

Sweden (4 teams; 448-173/446-175)

Huddinge, Huddinge University Hospital#, CIC 212, P Ljungmann (329-38/329-38); Lund, University Hospital*, CIC 283, A Bekassy (44-58/44-58); Umea, Umea University Hospital°, CIC 731, A Wahlin (2-9/1-10); Uppsala, University Children's Hospital*, CIC 266, J Arvidson (73-68/72-69).

Switzerland (9 teams; 300-162/300-162)

Basel, Basler Kinderspital Abt. Hämato-Onkologie°, CIC 202, A Gratwohl (166-33/166-33); Bellinzona, Ist. Oncol. della Svizzera Italiana °, CIC 829, L Leoncini (0-1/0-1); Bern, University Hospital°, CIC 221, K Leibundgut, M Fey (0-44/0-44); Geneva, Hopital Cantonal Universitarie*, CIC 261, P Wacker (38-16/38-16); Lausanne, Centre Hospitalier Universitaire Vaudois*, CIC 820, M Nenadov-Beck (0-18/0-18); St Gallen, Kantonsspital°, CIC 324, U Hess (0-6/0-6); Zurich, University Hospital°, CIC 208, U Schanz (13-13/13-13); Zurich, University Children's Hospital*, CIC 334, R Seger (81-31/81-31); Zurich, Klinik Im Park°, CIC 700, V Hofmann (2-0/2-0).

Turkey (2 teams; 47-19/48-19)

Ankara, Gülhane Military Medical Academy°, CIC 372, F Arpaci (8-9/8-9); Antalya, Akdeniz University Medical School*, CIC 618, MA Yesilipek (39-10/40-10).

United Kingdom (20 teams; 2,034-737/2,099-744)

Bangor, Ysbyty Gwynedd Hospital°, CIC 736, MH Gilleece (0-1/0-1); Belfast, Belfast City Hospital°, CIC 268, F Jones (4-4/19-3); Birmingham, Heartlands Hospital°, CIC 284, DW Milligan (2-12/2-13); Birmingham, Children's Hospital*, CIC 781, P Darbyshire (267-61/268-60); Bristol, Royal Hospital for Children*, CIC 386, J Cornish (583-93/558-85); Cardiff, University of Wales°, CIC 303, AK Burnett (7-0/7-0); Edinburgh, Western General Hospital°, CIC 228, J Davies (13-4/13-4); Glasgow, Royal Hospital for Sick Children*, CIC 707, B Gibson (87-30/85-31); Leicester, Royal Infirmary°, CIC 713, A Hunter (21-17/23-17); London, Hammersmith Hospital°, CIC 205, J Apperley (274-9/274-9); London, University College Hospital°, CIC 224, A Goldstone (39-74/44-77); London, Great Ormond Street Hospital*, CIC 243, P Veys (340-172/391-188); Manchester, Christie NHS Trust Hospital°, CIC 780, E Liakopoulou (6-22/6-22); Manchester, Royal Manchester Children's Hospital*, CIC 521, RF Wynn (275-119/282-119); Norwich, The Norfolk and Norwich University Hospital°, CIC 391, J Parker (0-1/0-1); Nottingham, City Hospital°, CIC 717, N Russell (10-8/10-8); Oxford, Radcliffe Hospital*, CIC 255, T Littlewood (11-36/10-36); Sheffield, Children's Hospital*, CIC 778, A Vora (79-38/85-32); Southampton, General Hospital°, CIC 704, K Orchard (16-35/22-37); Stoke on Trent, North Staffordshire Hospital°, CIC 394, R Chasty (0-1/0-1).

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Miano, M., Cancedda, R., Hartmann, O. et al. Survey on haematopoietic stem cell transplantation for children in Europe. Bone Marrow Transplant 35 (Suppl 1), S3–S8 (2005). https://doi.org/10.1038/sj.bmt.1704834

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