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Centre Effects

Evaluation of centre and period effects in allogeneic haematopoietic stem cell transplantation in France

Bone Marrow Transplantation volume 34, pages 645–651 (2004)Cite this article

Summary:

We evaluated the effect of individual and collective factors on the outcome of allogeneic haematopoietic stem cell transplantation (HSCT) at 35 French centres. Individual factors included patient and transplantation characteristics. Collective factors were related to the period and centre in which HSCT was performed. Two centre factors were studied: centre experience (ie number of HSCT performed during the study period) and the type of centre (paediatric or adult). All patients receiving a first allogeneic HSCT in France between 1st January 1993 and 31st December 1997 were included in the study. The follow-up period ended on 31st December 1997. The final sample included 2756 subjects. We analysed overall survival (OS) and transplant-related mortality (TRM). Prognostic factors were identified by univariate and multivariate analysis, using Cox models. We found that centre experience had no significant effect on outcome. However, survival rates, whether determined on the basis of OS or TRM, were significantly higher in paediatric centres than in adult centres. Residual heterogeneity was found between adult centres. Survival rates were significantly higher for HSCT performed after 1st January 1996 than for those performed before this date.

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Acknowledgements

We would like to thank the following HSCT centres affiliated to the Société Française de Greffe de Moelle et de Thérapie Cellulaire for providing high-quality data:

Hôpital de l'Hôtel Dieu, Angers; Hôpital Jean Minjoz, Besançon; Hôpital Percy, Clamart; Centre Jean Perrin and Hôpital de l'Hôtel Dieu, Clermont Ferrand; Hôpital Henri Mondor, Créteil; Hôpital Albert Michallon, Grenoble; Hôpital Huriez, Lille; Hôpital Edourd Herriot and Hôpital Debrousse, Lyon; Hôpital de la Timone and Institut Paoli Calmettes, Marseille; Hôpital Lapeyronie and Hôpital Arnaud de Villeneuve, Montpellier; Hôpitaux de Brabois, Nancy; Hôpital de l'Hôtel Dieu, Nantes; Hôpital de l'Archet, Nice; Hôpital de l'Hôtel Dieu, Hôpital Necker, Hôpital de la Pitié Salpêtrière, Hôpital Robert Debré, Hôpital Saint-Antoine, Hôpital Saint-Louis, Paris; Hôpital du Haut Lévêque, Pessac; Hôpital Jean Bernard, Poitiers; Hôpital de Pontchaillou, Rennes; Centre Henri Becquerel and Hôpital Charles Nicolle, Rouen; Hôpital Nord, Saint-Etienne; Hôpital de Hautepierre, Strasbourg; Hôpital Purpan, Toulouse; Institut Gustave Roussy, Villejuif.

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Authors and Affiliations

  1. Etablissement Français des Greffes, Paris, France

    F Mesnil, J-P Jouet & P Tuppin

  2. Société Française de Greffe de Moelle et de Thérapie Cellulaire, Paris, France

    J-P Jouet & J-P Vernant

  3. Hôpital Pitié-Salpêtrière, Paris, France

    F Mesnil, J-P Vernant & J-L Golmard

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  1. F Mesnil
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Correspondence to F Mesnil.

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Mesnil, F., Jouet, JP., Tuppin, P. et al. Evaluation of centre and period effects in allogeneic haematopoietic stem cell transplantation in France. Bone Marrow Transplant 34, 645–651 (2004). https://doi.org/10.1038/sj.bmt.1704622

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