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Successful use of Campath-1H in the treatment of steroid refractory liver GvHD

Bone Marrow Transplantation volume 34, pages 285–287 (2004)Cite this article

Graft-versus-host disease (GvHD) is one of the major limitations to successful haematopoietic stem cell transplantation and occurs in 20–90% of patients following allogeneic stem cell transplant.1 Corticosteroids are the backbone of most treatment regimens for acute GvHD, but fewer than 50% of patients show a durable response to corticosteroids.2 Steroid-resistant acute GvHD is associated with high morbidity and mortality and is extremely difficult to manage.3 Various pharmacological agents like antithymocyte globulin4 and mycophenolate mofetil5 have been used with variable responses. Recently, a number of monoclonal antibodies (anti-IL-1, anti-TNF, anti-IL-2 and anti-CD3 antibody) have been tried in steroid refractory acute GvHD with mixed results.6

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Authors and Affiliations

  1. Department of Haematology, Bone Marrow Transplant Unit, University Hospital Birmingham NHS Trust, Birmingham, UK

    F Wandroo, B Auguston, M Cook, C Craddock & P Mahendra

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  1. F Wandroo
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  2. B Auguston
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  3. M Cook
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  4. C Craddock
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  5. P Mahendra
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Wandroo, F., Auguston, B., Cook, M. et al. Successful use of Campath-1H in the treatment of steroid refractory liver GvHD. Bone Marrow Transplant 34, 285–287 (2004). https://doi.org/10.1038/sj.bmt.1704573

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