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Infections Post Transplant

Herpes simplex virus infection in adult patients after unrelated cord blood transplantation: a single-institute experience in Japan

Bone Marrow Transplantation volume 33, pages 317–320 (2004)Cite this article

Summary:

Herpes simplex virus (HSV) infection in adult patients who underwent cord blood transplantation (CBT) from unrelated donors was studied. None of nine HSV-seronegative patients developed HSV disease after CBT. Of 28 HSV-seropositive patients, seven (25%) developed HSV disease at a median of 92 days after CBT (range, 52–239 days). The cumulative incidence of HSV disease in HSV-seropositive patients was 27% at 12 months after CBT. The manifestations of HSV disease included gingivostomatitis (three patients), herpes labialis (two patients), localized herpes facialis of the nose (one patient), and disseminated eczema herpeticum (one patient). HSV disease recurred in two patients as gingivostomatitis and disseminated eczema herpeticum. All the patients responded to antiviral therapy. The presence of grade II–IV acute graft-versus-host disease (GVHD) was significantly associated with a higher rate of HSV disease after CBT (51 vs 8%, P=0.015). These results suggest that the recovery of HSV-specific immune responses is delayed in patients who develop grade II–IV acute GVHD after CBT.

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References

  1. Burns WH . Herpes simplex virus infections. In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation. Blackwell Scientific Publications: Oxford, 1999, pp 584–590.

    Google Scholar 

  2. Ramsey PG, Fife KH, Hackman RC et al. Herpes simplex virus pneumonia: clinical, virologic, and pathologic features in 20 patients. Ann Intern Med 1982; 97: 813–820.

    Article  CAS  Google Scholar 

  3. Johnson JR, Egaas S, Gleaves CA et al. Hepatitis due to herpes simplex virus in marrow-transplant recipients. Clin Infect Dis 1992; 14: 38–45.

    Article  CAS  Google Scholar 

  4. Chakrabarti S, Pillay D, Ratcliffe D et al. Resistance to antiviral drugs in herpes simplex virus infections among allogeneic stem cell transplant recipients: risk factors and prognostic significance. J Infect Dis 2000; 181: 2055–2058.

    Article  CAS  Google Scholar 

  5. Chen Y, Scieux C, Garrait V et al. Resistant herpes simplex virus type 1 infection: an emerging concern after allogeneic stem cell transplantation. Clin Infect Dis 2000; 31: 927–935.

    Article  CAS  Google Scholar 

  6. Saral R, Burns WH, Laskin OL et al. Acyclovir prophylaxis of herpes-simplex-virus infections. N Engl J Med 1981; 305: 63–67.

    Article  CAS  Google Scholar 

  7. Wade JC, Newton B, Flournoy N, Meyers JD . Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med 1984; 100: 823–838.

    Article  CAS  Google Scholar 

  8. Reusser P, Cordonnier C, Einsele H et al. European survey of herpesvirus resistance to antiviral drugs in bone marrow transplant recipients. Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 1996; 17: 813–817.

    CAS  Google Scholar 

  9. Sanz GF, Saavedra S, Planelles D et al. Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood 2001; 98: 2332–2338.

    Article  CAS  Google Scholar 

  10. Laughlin MJ, Barker J, Bambach B et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344: 1815–1822.

    CAS  Google Scholar 

  11. Ooi J, Iseki T, Takahashi S et al. Unrelated cord blood transplantation for adult patients with advanced myelodysplastic syndrome. Blood 2003; 101: 4711–4713.

    Article  CAS  Google Scholar 

  12. Saavedra S, Sanz GF, Jarque I et al. Early infections in adult patients undergoing unrelated donor cord blood transplantation. Bone Marrow Transplant 2002; 30: 937–943.

    Article  CAS  Google Scholar 

  13. Tomonari A, Iseki T, Ooi J et al. Cytomegalovirus infection following unrelated cord blood transplantation for adult patients: a single institute experience in Japan. Br J Haematol 2003; 121: 304–311.

    Article  Google Scholar 

  14. Tomonari A, Iseki T, Takahashi S et al. Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan. Br J Haematol 2003; 122: 802–805.

    Article  Google Scholar 

  15. Harris DT, Schumacher MJ, Locascio J et al. Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proc Natl Acad Sci USA 1992; 89: 10006–10010.

    Article  CAS  Google Scholar 

  16. Thomson BG, Robertson KA, Gowan D et al. Analysis of engraftment, graft-versus-host disease, and immune recovery following unrelated donor cord blood transplantation. Blood 2000; 96: 2703–2711.

    CAS  Google Scholar 

Download references

Acknowledgements

We thank Maki Monna-Oiwa for her secretarial assistance. We also thank the KOBAYASHI Foundation for financial support.

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Authors and Affiliations

  1. Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    A Tomonari, S Takahashi, T Iseki, J Ooi, T Yamada, K Takasugi, Y Shimohakamada, N Ohno, F Nagamura, K Uchimaru, K Tani, A Tojo & S Asano

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  1. A Tomonari
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Correspondence to A Tomonari.

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Tomonari, A., Takahashi, S., Iseki, T. et al. Herpes simplex virus infection in adult patients after unrelated cord blood transplantation: a single-institute experience in Japan. Bone Marrow Transplant 33, 317–320 (2004). https://doi.org/10.1038/sj.bmt.1704343

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  • DOI: https://doi.org/10.1038/sj.bmt.1704343

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