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Myelofibrosis

FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia

Bone Marrow Transplantation volume 32, pages 581–585 (2003)Cite this article

Summary:

A 38-year-old woman with agnogenic myeloid metaplasia complicated by the poor prognostic factors of severe osteosclerosis, prominent hepatosplenomegaly, and profound anemia was treated with FLAG chemotherapy to decrease her organomegaly before undergoing a nonmyeloablative allogeneic stem cell transplant from a matched-sibling donor. The patient's pre- and post transplant course were complicated by an autoimmune disorder and her post transplant course was complicated by severe hepatic and gastrointestinal GVHD. A technetium-99m sulfur colloid scan 4 months post transplant and bone marrow studies 8 months post transplant demonstrated intramedullary hematopoiesis, complete resolution of marrow fibrosis, and partial resolution of osteosclerosis.

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Authors and Affiliations

  1. University of California, San Diego School of Medicine, La Jolla, CA, USA

    M L Tanner

  2. Department of Radiology, University of California, San Diego School of Medicine, La Jolla, CA, USA

    C K Hoh

  3. Department of Medicine and Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA

    A Bashey, P Holman, C Sun, E D Ball & E Carrier

  4. Department of Pathology, University of California, San Diego School of Medicine, La Jolla, CA, USA

    H E Broome & T Lane

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  1. M L Tanner
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Correspondence to E Carrier.

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Tanner, M., Hoh, C., Bashey, A. et al. FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia. Bone Marrow Transplant 32, 581–585 (2003). https://doi.org/10.1038/sj.bmt.1704172

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  • DOI: https://doi.org/10.1038/sj.bmt.1704172

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