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Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases

Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?

Bone Marrow Transplantation volume 32, pages S65–S67 (2003)Cite this article

Summary:

Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.

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Authors and Affiliations

  1. Division of Immunotherapy, Department of Medicine, Chicago, Northwestern University Medical Center, IL, USA

    R K Burt, Yu Oyama, A Traynor, K Quigley, M Brush, J Rodriguez & W G Barr

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  1. R K Burt
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  2. Yu Oyama
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  3. A Traynor
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  4. K Quigley
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  5. M Brush
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  6. J Rodriguez
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  7. W G Barr
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Burt, R., Oyama, Y., Traynor, A. et al. Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?. Bone Marrow Transplant 32 (Suppl 1), S65–S67 (2003). https://doi.org/10.1038/sj.bmt.1704055

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