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Successful application of epidermal growth factor for treatment of hemorrhagic cystitis after bone marrow transplantation

Bone Marrow Transplantation volume 31, pages 615–616 (2003)Cite this article

Hemorrhagic cystitis (HC) is a common complication after bone marrow transplantation, with an incidence that varies from 7 to 68% in different reports. It can occur early or late after transplantation. Early onset of HC has been associated mainly with administration of cyclophosphamide and busulfan. These drugs can damage the uroepithelium directly, or through metabolites, whereas late onset (2–3 months after transplant) HC has been related instead to reactivation of virus infection.1

Initial treatment is usually forced diuresis and continuous bladder irrigation (CBI). Other measures like MESNA and prostaglandins are still under debate.2 Some authors reported encouraging results using hyperbaric therapy.3 Recently, recombinant human granulocyte–macrophage colony-stimulating factor (rhGM-CSF) in intravesical instillation has been reported for the treatment of HC.4 Generally, HC can be managed by medical therapy but in cases of refractoriness it may require cystotomy or cystectomy.

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Authors and Affiliations

  1. Department of Hemopoietic Transplantation, Institute of Hematology and Immunology, La Habana, Cuba

    E Dorticós, V Pavón, J C Jaime, M Reboredo & P Hernández

  2. Center of Biological Investigations, La Habana, Cuba

    P López Saura & J Berlanga

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  1. E Dorticós
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  2. V Pavón
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  3. J C Jaime
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  4. M Reboredo
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  5. P López Saura
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  6. J Berlanga
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  7. P Hernández
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Dorticós, E., Pavón, V., Jaime, J. et al. Successful application of epidermal growth factor for treatment of hemorrhagic cystitis after bone marrow transplantation. Bone Marrow Transplant 31, 615–616 (2003). https://doi.org/10.1038/sj.bmt.1703877

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  • DOI: https://doi.org/10.1038/sj.bmt.1703877

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