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Progenitor Cell Mobilisation

Granulocyte colony-stimulating factor alone at 12 μg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients

Bone Marrow Transplantation volume 30, pages 417–420 (2002)Cite this article

Abstract

In children, the optimal mobilization schedule for harvesting peripheral blood progenitor cells (PBPC) is an issue of continuous research. We have studied a schedule based on high and daily divided doses of G-CSF (12 μg/kg body weight twice daily) for 4 days for PBPC priming. Toxicity related to G-CSF was observed in 13 patients (23%), mainly mild bone pain and myalgia. The median CD34+cell number collected was 4.4 (0.4–35 × 106/kg body weight), with 46 patients achieving 2 × 106/kg body weight (83.6%) after a single large volume leukapheresis. In conclusion, this mobilization schedule allows safe and efficient collection of the minimum target CD34+ cell dose in most pediatric patients by only one procedure.

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Authors and Affiliations

  1. Hospital Infantil Universitario Niño Jesús, Madrid, Spain

    J Sevilla, M González-Vicent, L Madero & MA Díaz

  2. Centro de Tranfusión de la Comunidad de Madrid, Madrid, Spain

    F García-Sánchez

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  1. J Sevilla
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  2. M González-Vicent
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  3. L Madero
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  4. F García-Sánchez
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  5. MA Díaz
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Sevilla, J., González-Vicent, M., Madero, L. et al. Granulocyte colony-stimulating factor alone at 12 μg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients. Bone Marrow Transplant 30, 417–420 (2002). https://doi.org/10.1038/sj.bmt.1703662

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