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Chronic active Epstein–Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation

Abstract

We report a pediatric case of CAEBV and T cell-based Hodgkin's-like disease successfully treated with allo PBSCT from an HLA-matched sibling. The diagnosis of CAEBV was made from clinical signs and the presence of the EBV genome in PBMC and tumor cells. Conditioning with busulfan (BU) + etoposide (VP16) + cyclophosphamide (CY) was effective and well tolerated. EBV was totally eradicated by 3 months after allo PBSCT. Although she suffered from chronic GVHD of the liver, she has been well and free of disease for 47 months since PBSCT. We suggest allo PBSCT for CAEBV as a potent therapeutic strategy for eradication of the EBV genome and allowing immunological reconstitution.

Bone Marrow Transplantation (2002) 29, 531–533. doi:10.1038/sj.bmt.1703392

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References

  1. Rickinson AB . Chronic, symptomatic Epstein–Barr virus infections Immunol Today 1986 7: 13 15

    Article  CAS  PubMed  Google Scholar 

  2. Ishida Y, Yokota Y, Tauchi H et al. Ganciclovir for chronic active Epstein–Barr virus infection Lancet 1993 341: 560 561

    Article  CAS  PubMed  Google Scholar 

  3. Sakai Y, Ohga S, Tonegawa Y et al. Interferon α therapy for chronic active Epstein–Barr virus infection: potential effect on the development of T-lymphoproliferative disease J Pediatr Hematol Oncol 1998 20: 342 346

    Article  CAS  PubMed  Google Scholar 

  4. Kawa-Ha K, Franco E, Doi S et al. Successful treatment of chronic active Epstein–Barr virus infection with recombinant interleukin-2 Lancet 1987 i: 154

    Article  Google Scholar 

  5. Kuzushima K, Yamamoto M, Kimura H et al. Establishment of Epstein–Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection Clin Exp Immunol 1996 103: 192 198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kimura H, Morita M, Yabuta Y et al. Quantitative analysis of Epstein–Barr virus load by using a real-time PCR assay J Clin Microbiol 1999 37: 132 136

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Su IJ, Hsieh HC . Clinicopathological spectrum of Epstein–Barr virus-associated T cell malignancies Leuk Lymphoma 1992 7: 47 53

    Article  CAS  PubMed  Google Scholar 

  8. Teshima T, Miyaji R, Fukuda M et al. Bone marrow transplantation for Epstein–Barr virus-associated natural killer cell-large granular lymphocyte leukemia Lancet 1996 347: 1124

    Article  CAS  PubMed  Google Scholar 

  9. Imashuku S, Naya M, Yamori M et al. Bone marrow transplantation for Epstein–Barr virus-related clonal T cell proliferation associated with hemophagocytosis Bone Marrow Transplant 1997 19: 1059 1060

    Article  CAS  PubMed  Google Scholar 

  10. Takami A, Nakao S, Yachie A et al. Successful treatment of Epstein–Barr virus-associated natural killer cell large granular lymphocytic leukemia using allogeneic peripheral blood stem cell transplantation Bone Marrow Transplant 1998 21: 1279 1282

    Article  CAS  PubMed  Google Scholar 

  11. Fujii N, Takenaka K, Hiraki A et al. Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein–Barr virus infection Bone Marrow Transplant 2000 26: 805 808

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We are grateful to Koh Kaneko MD (Department of Pathology, Japan Red Cross Ohmiya Hospital) for his help.

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Taketani, T., Kikuchi, A., Inatomi, J. et al. Chronic active Epstein–Barr virus infection (CAEBV) successfully treated with allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 29, 531–533 (2002). https://doi.org/10.1038/sj.bmt.1703392

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  • DOI: https://doi.org/10.1038/sj.bmt.1703392

Keywords

  • CAEBV
  • malignant lymphoma
  • allo PBSCT
  • EBV in situ hybridization

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