Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Lamivudine treatment for reverse seroconversion of hepatitis B 4 years after allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 29, pages 361–363 (2002)Cite this article

Abstract

Reverse seroconversion of hepatitis B virus (HBV) after allogeneic BMT is rare. We present a case of HBV reactivation late after allogeneic BMT which responded well to lamivudine therapy. A 35-year-old woman with CML received an allogeneic BMT. Before BMT, the patient had immunity to HBV, with serum antibodies against hepatitis B surface antigen (HBsAb), and the donor was completely negative for HBV. Four years after BMT, acute hepatitis occurred with a detectable level of HBV-DNA. Lamivudine rapidly reduced transaminase and bilirubin levels, and serum HBV-DNA decreased to negative. Retrospective analysis revealed that there had been a gradual decrease in serum HBsAb titers after BMT. Administration of lamivudine immediately after HBV replication may be more effective than vaccination of hepatitis B surface antigen-negative donors before BMT.

Bone Marrow Transplantation (2002) 29, 361–363. doi:10.1038/sj.bmt.1703387

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Martin BA, Rowe JM, Koudes PA, DiPersio JF . Hepatitis B reactivation following allogeneic bone marrow transplantation: case report and review of the literature Bone Marrow Transplant 1995 15: 145 148

    CAS  Google Scholar 

  2. Dienstag JL, Schiff ER, Wright TL et al. Lamivudine as initial treatment for chronic hepatitis B in the United States New Engl J Med 1999 341: 1256 1263

    Article  CAS  Google Scholar 

  3. Picardi M, Selleri C, De Rosa G et al. Lamivudine treatment for chronic replicative hepatitis B virus infection after allogeneic bone marrow transplantation Bone Marrow Transplant 1998 21: 1267 1269

    Article  CAS  Google Scholar 

  4. Uchida N, Gondo H, Himeji D et al. Lamivudine therapy for a hepatitis B surface antigen (HBsAg)-positive leukemia patient receiving myeloablative chemotherapy and autologous stem cell transplantation Bone Marrow Transplant 2000 26: 1243 1245

    Article  CAS  Google Scholar 

  5. Locasciulli A, Bacigalupo A, Van List MT et al. Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: a report of 30 cases Bone Marrow Transplant 1990 6: 25 29

    CAS  PubMed  Google Scholar 

  6. Fan FS, Tzeng CH, Yeh HM, Chen PM . Reverse seroconversion of hepatitis B virus infectious status after allogeneic bone marrow transplantation from a carrier donor Bone Marrow Transplant 1992 10: 189 191

    CAS  PubMed  Google Scholar 

  7. Greenberg HB, Pollard RB, Lutwick LI et al. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis New Engl J Med 1976 295: 517 522

    Article  CAS  Google Scholar 

  8. Skoskiewicz MG, Colvin RB, Schneerburger EE, Russel PS . Histocompatibility complex-determined antigens in vivo by gamma interferon J Exp Med 1985 162: 1645 1664

    Article  CAS  Google Scholar 

  9. Serrano J, Prieto E, Mazarbeitia F et al. Atypical chronic graft-versus-host disease following interferon therapy for chronic myeloid leukemia relapsing after allogeneic BMT Bone Marrow Transplant 2001 27: 85 87

    Article  CAS  Google Scholar 

  10. Reshef R, Sbeit W, Tur-Kaspa R . Lamivudine in the treatment of acute hepatitis B New Engl J Med 2000 343: 1123 1124

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    S Hashino, A Nozawa, K Izumiyama, M Yonezumi, K Chiba, T Kondo, S Suzuki, S Hige & M Asaka

Authors
  1. S Hashino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Nozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K Izumiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Yonezumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K Chiba
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Kondo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S Hige
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M Asaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hashino, S., Nozawa, A., Izumiyama, K. et al. Lamivudine treatment for reverse seroconversion of hepatitis B 4 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 29, 361–363 (2002). https://doi.org/10.1038/sj.bmt.1703387

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703387

Keywords

This article is cited by

Search

Advanced search

Quick links