Abstract
A 21-year-old woman with severe aplastic anemia underwent allogeneic bone marrow transplantation from an HLA-identical sibling donor. The patient also had chronic hepatitis B and the donor was an HBV carrier. To decrease HBV and improve hepatic dysfunction before BMT, the patient had received lamivudine for 6 months. After marrow transfusion, administration of lamivudine was continued to inhibit replication of donor-derived HBV. The patient showed hematological engraftment on day 13 without any serious liver dysfunction. Eight months after BMT, she is now alive and well without chronic liver GVHD or reactivation of hepatitis B. HBV-DNA was not detected in the patient's serum. Administration of lamivudine to a BMT recipient with chronic hepatitis B may be a safe and promising way to prevent fatal liver dysfunction in the setting of allogeneic BMT, even in the event of BMT from an HBV-positive donor.
Bone Marrow Transplantation (2002) 29, 269–271. doi:10.1038/sj.bmt.1703350
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ustun C, Koc H, Karayalcin S et al. Hepatitis B virus infection in allogeneic bone marrow transplantation Bone Marrow Transplant 1997 20: 289 296
Mertens T, Kock J, Hampl W et al. Reactivated fulminant hepatitis B virus replication after bone marrow transplantation: clinical course and possible treatment with ganciclovir J Hepatol 1995 25: 968 971
Lau GKK, Liang R, Chiu EKW et al. Hepatic events after bone marrow transplantation in patients with hepatitis B infection: a case controlled study Bone Marrow Transplant 1997 19: 795 799
Locasciulli A, Alberti A, Bandini G et al. Allogeneic bone marrow transplantation from HBsAg+ donors: a multicenter study from the Gruppo Italiano Trapiano di Midolo Osseo (GITMO) Blood 1995 86: 3236 3240
Lai C-L, Chien R-N, Leung NWY et al. A one-year treatment of lamivudine for chronic hepatitis B New Engl J Med 1998 339: 61 68
Dienstag JL, Schiff ER, Wright TL et al. Lamivudine as initial treatment for chronic hepatitis B in the United States New Engl J Med 1998 341: 1256 1263
Picardi M, Selleri C, DeRosa G et al. Lamivudine treatment for chronic replicative hepatitis B virus infection after allogeneic bone marrow transplantation Bone Marrow Transplant 1998 21: 1267 1269
Al-Taie OH, Mork H, Gassel AM et al. Prevention of hepatitis B flare-up during chemotherapy using lamivudine: case report and review of the literature Ann Hematol 1999 78: 247 249
Nevens F, Main J, Honkoop P et al. Lamivudine therapy for chronic hepatitis B: a six-month randomized dose-ranging study Gastroenterol 1997 113: 1258 1263
Dienstag LJ, Perrillo RP, Schiff ER et al. A preliminary trial of lamivudine for chronic hepatitis B infection New Engl J Med 1995 333: 1657 1661
Uchida N, Gondo H, Himeji D et al. Lamivudine therapy for a hepatitis B surface antigen (HBsAg)-positive leukemia patient receiving myeloablative chemotherapy and autologous stem cell transplantation Bone Marrow Transplant 2000 26: 1243 1245
Reshef R, Sbeit W, Tur-Kaspa R . Lamivudine in the treatment of acute hepatitis B New Engl J Med 2000 343: 1123 1124
Liaw YF, Chien RN, Yeh CT et al. Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy Hepatology 1999 30: 567 572
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hashino, S., Takahata, M., Nozawa, A. et al. Successful allogeneic bone marrow transplantation from an HBV-positive donor into an HBV-positive recipient using lamivudine. Bone Marrow Transplant 29, 269–271 (2002). https://doi.org/10.1038/sj.bmt.1703350
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703350
Keywords
This article is cited by
-
Lamivudine treatment for acute hepatitis B virus infection during allogeneic peripheral blood stem cell transplantation
Bone Marrow Transplantation (2003)