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Nonmyeloablative allogeneic bone marrow transplantation for orbital granulocytic sarcoma associated with t(8;21)(q22;q22) in acute myeloid leukemia

Bone Marrow Transplantation volume 29, pages 67–70 (2002)Cite this article

Abstract

We report a nonmyeloablative allogeneic bone marrow transplant (allo-BMT) from an HLA-matched unrelated donor in a case of acute myeloid leukemia (AML), M2 with t(8;21)(q22;q22) and the presence of orbital granulocytic sarcoma (GS), who had residual tumor after conventional chemotherapy. The course of BMT was well tolerated, with no major procedure-related toxicity. The residual orbital GS regressed completely 4 months after BMT. She is currently 19 months post BMT, disease-free. To our knowledge, this is the first reported pediatric patient with AML, GS and t(8;21)(q22;q22) who received a nonmyeloablative allo-BMT.

Bone Marrow Transplantation (2002) 29, 67–70. doi:10.1038/sj.bmt.1703316

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Authors and Affiliations

  1. Department of Pediatrics, Taipei Veterans General Hospital, Tapei, Taiwan, ROC

    G-Y Hung, Y-L Hsieh & B Hwang

  2. Department of Medicine, Section of Medical Oncology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC

    T-J Chiou & P-M Chen

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  1. G-Y Hung
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  2. T-J Chiou
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  3. Y-L Hsieh
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  4. P-M Chen
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  5. B Hwang
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Hung, GY., Chiou, TJ., Hsieh, YL. et al. Nonmyeloablative allogeneic bone marrow transplantation for orbital granulocytic sarcoma associated with t(8;21)(q22;q22) in acute myeloid leukemia. Bone Marrow Transplant 29, 67–70 (2002). https://doi.org/10.1038/sj.bmt.1703316

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