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Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population

Bone Marrow Transplantation volume 28, pages 717–720 (2001)Cite this article

Abstract

We report a case of autologous hematopoietic recovery with durable leukemic remission after BMT from a phenotypically HLA-identical donor in a 30-year-old male with CML. Graft loss was diagnosed from day 60 post-BMT by VNTR PCR. To assess for the presence of a minor donor-derived T cell population that could exert an anti-leukemic effect, we serially applied a sensitive process of chimerism analysis by fluorescent PCR on sorted T cells. No residual donor T cells could be detected. We also showed retrospectively that a very sensitive method of MRD analysis by real-time quantitative PCR could have permitted prediction of relapse in this case. Bone Marrow Transplantation (2001) 28, 717–720.

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Authors and Affiliations

  1. Department of Hematology, Henri Mondor Hospital, Créteil, France

    S Maury, K Belhadj, M Kuentz & C Cordonnier

  2. Laboratory of Hematology, Henri Mondor Hospital, Créteil, France

    I Chami & D Bories

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  1. S Maury
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  2. K Belhadj
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  3. I Chami
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  4. M Kuentz
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  5. C Cordonnier
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  6. D Bories
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Maury, S., Belhadj, K., Chami, I. et al. Autologous reconstitution combined with durable leukemic remission after allogeneic BMT for CML: absence of persistence of a donor-derived T cell effector population. Bone Marrow Transplant 28, 717–720 (2001). https://doi.org/10.1038/sj.bmt.1703218

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  • DOI: https://doi.org/10.1038/sj.bmt.1703218

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