Respiratory syncytial virus (RSV) infection is an important cause of respiratory mortality in immunosuppressed patients, including bone marrow transplant (BMT) recipients. The presence of lower respiratory tract infection and infection in the pre-engraftment phase of BMT is believed to confer a poor prognosis. Three patients who underwent allogeneic BMT at our institution developed RSV pneumonia over 1 year post BMT, with the underlying disease in remission. All three were hypoxic with extensive pulmonary disease at presentation. Treatment consisted of aerosolized ribavirin and intravenous immune globulin with successful clearing of viral shedding and excellent clinical outcomes. RSV infection is probably less severe in the late post-BMT period, but needs to be considered early in the differential diagnosis of pulmonary infiltrates in this patient population. Bone Marrow Transplantation (2001) 27, 1071–1073.
This is a preview of subscription content, access via your institution
Subscribe to Journal
Get full journal access for 1 year
only $9.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Whimbey E, Englund JA, Couch RB . Community respiratory virus infections in immunocompromised patients with cancer Am J Med 1997 102: 10–18
Harrington RD, Hooton TM, Hackman RC et al. An outbreak of respiratory syncytial virus in a bone marrow transplant center J Infect Dis 1992 165: 987–993
McColl MD, Corser RB, Bremmer J et al. Respiratory syncitial virus infection in adult BMT recipients: effective therapy with short duration nebulised ribavirin Bone Marrow Transplant 1998 21: 423–425
McCarthy AJ, Kingman HM, Kelly C et al. The outcome of 26 patients with respiratory syncytial virus infection following allogeneic stem cell transplantation Bone Marrow Transplant 1999 24: 1315–1322
Hertz MI, Englund JA, Snover D et al. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature Medicine 1989 68: 269–281
Meyers JD, Flournoy N, Thomas ED . Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience Rev Infect Dis 1982 4: 1119–1132
Whimbey E, Champlin RE, Couch RB et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Clin Infect Dis 1996 22: 778–782
Ljungman P, Gleaves CA, Meyers JD . Respiratory virus infection in immunocompromised patients Bone Marrow Transplant 1989 4: 35–40
Englund JA, Sullivan CJ, Colin Jordan M et al. Respiratory syncytial virus infection in immunocompromised adults Ann Intern Med 1988 109: 203–208
Ghosh S, Champlin RE, Englund J et al. Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin Bone Marrow Transplant 2000 25: 751–755
About this article
Cite this article
Khushalani, N., Bakri, F., Wentling, D. et al. Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplant 27, 1071–1073 (2001). https://doi.org/10.1038/sj.bmt.1703046
- RSV infection
Active surveillance for respiratory virus infections in adults who have undergone bone marrow and peripheral blood stem cell transplantation
Bone Marrow Transplantation (2003)
Bone Marrow Transplantation (2002)