Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Resolution of sarcoidosis after allogeneic bone marrow transplantation with donor lymphocyte infusions

Bone Marrow Transplantation volume 27, pages 757–759 (2001)Cite this article

Abstract

Abnormalities of immune surveillance may contribute to the development of myeloid malignancy as well as immune-mediated diseases. In leukaemia, allogeneic haemopoietic stem cell transplantation (alloHSCT) has been used to induce disease remission, in part by restoring mechanisms of immune regulation. Although, by the same principle, allogeneic stem cell transplantation is an attractive option for the treatment of immunological disorders, it is unclear whether remission after transplantation is due to pre-transplant conditioning, or modulation of auto-reactive lymphocytes by cells in the allograft. We report the case of a patient with chronic myeloid leukaemia (CML) who received an allogeneic bone marrow transplant (alloBMT) from his brother. He subsequently suffered a cytogenetic and molecular relapse of CML. At the same time, sarcoidosis involving the marrow was diagnosed. He was treated with donor lymphocyte infusions (DLI) and attained remission from CML; in addition, no giant cell granulomas were detected in the marrow, indicating resolution of sarcoidosis. This case illustrates the need for further studies on the role of T cell-based therapies in the management of immune-mediated disorders. Bone Marrow Transplantation (2001) 27, 757–759.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Tsuda H, Yamasaki H . Type I and II T cell profiles in chronic myelogenous leukemia Acta Haematol 2000 103: 96–101

    Article  CAS  Google Scholar 

  2. Barrett AJ . Mechanisms of the graft-versus-leukemia reaction Stem Cells 1997 15: 248–258

    Article  CAS  Google Scholar 

  3. Dazzi F, Szydlo RM, Goldman JM . Donor lymphocyte infusions for relapse of chronic myeloid leukemia after allogeneic stem cell transplant: where we now stand Exp Hematol 1999 27: 1477–1486

    Article  CAS  Google Scholar 

  4. Ring GH, Lakkis FG . Breakdown of self-tolerance and the pathogenesis of autoimmunity Semin Nephrol 1999 19: 25–33.

    CAS  PubMed  Google Scholar 

  5. Burt RK, Traynor AE . Haemopoietic stem cell transplantation: a new therapy for autoimmune disease Stem Cells 1999 17: 366–372

    Article  CAS  Google Scholar 

  6. Yin JA, Jowitt SN . Resolution of immune-mediated diseases following allogeneic bone marrow transplantation for leukaemia Bone Marrow Transplant 1992 9: 31–33

    CAS  PubMed  Google Scholar 

  7. Snowden JA, Kearney P, Kearney A et al. Long-term outcome of autoimmune disease following allogeneic bone marrow transplantation Arthritis Rheum 1998 41: 453–459

    Article  CAS  Google Scholar 

  8. De Stefano P, Zecca M, Giorgiani G et al. Resolution of immune haemolytic anaemia with allogeneic bone marrow transplantation after an unsuccessful autograft Br J Haematol 1999 106: 1063–1064

    Article  CAS  Google Scholar 

  9. Lenhart K, Kolek V, Bartova A . HLA antigens associated with sarcoidosis Dis Markers 1990 8: 23–29

    CAS  PubMed  Google Scholar 

  10. Heyll A, Meckenstock G, Aul C et al. Possible transmission of sarcoidosis via allogeneic bone marrow transplantation Bone Marrow Transplant 1994 14: 161–164

    CAS  PubMed  Google Scholar 

  11. Small TN, Papadopoulos EB, Boulad F et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions Blood 1999 93: 467–480

    CAS  PubMed  Google Scholar 

  12. Vezendi S, Schroder I . Transfer factor therapy of sarcoidosis Allergol Immunopathol (Madr) 1989 17: 35–37

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone Marrow Transplant Unit, University Hospital Birmingham NHS Trust, Birmingham, UK

    S Tauro & P Mahendra

Authors
  1. S Tauro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P Mahendra
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tauro, S., Mahendra, P. Resolution of sarcoidosis after allogeneic bone marrow transplantation with donor lymphocyte infusions. Bone Marrow Transplant 27, 757–759 (2001). https://doi.org/10.1038/sj.bmt.1702874

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702874

Keywords

This article is cited by

Search

Advanced search

Quick links