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Umbilical cord blood transplantation from unrelated HLA-matched donor in an adult with severe aplastic anemia

Bone Marrow Transplantation volume 26, pages 1121–1123 (2000)Cite this article

Abstract

A 23-year-old male suffering from severe aplastic anemia (SAA) weighing 60 kg was successfully treated by unrelated allo-CBSCT (cord blood stem cell transplantation). A six-loci HLA-identical umbilical cord blood (UCB) was infused after conditioning with low-dose cyclophosphamide (CTX) and antilymphocyte globulin (ALG). The prophylaxis of GVHD consisted of CsA and MTX. The infused cord blood provided 1.89 × 107 nucleated cells per kg, cd34-positive cells: 0.89%. neutrophils >0.5 × 109/l were reached 10 days after transplant, and platelets greater than 50.0 × 109/l at day 26. RBC and platelet transfusion independence were reached on days 15 and 18. The patient developed grade 1 skin GVHD 10 months after engraftment of the donor cells. Microsatellite DNA fingerprinting indicated a stable and persistent donor–recipient mixed chimerism, whilst the circulating red cells remain of host origin. Bone Marrow Transplantation (2000) 26, 1121–1123.

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Authors and Affiliations

  1. Department of Haematology, First Municipal People's Hospital, Guangzhou, China

    P Mao, C Liao, Z Zhu, H Wang, S Wang, Y Xu, W Mo, Y Ying, Q Li & B Liu

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  1. P Mao
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  2. C Liao
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  3. Z Zhu
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  6. Y Xu
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  7. W Mo
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  9. Q Li
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  10. B Liu
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Mao, P., Liao, C., Zhu, Z. et al. Umbilical cord blood transplantation from unrelated HLA-matched donor in an adult with severe aplastic anemia. Bone Marrow Transplant 26, 1121–1123 (2000). https://doi.org/10.1038/sj.bmt.1702667

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