Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Complete remission of idiopathic myelofibrosis following donor lymphocyte infusion after failure of allogeneic transplantation: demonstration of a graft-versus-myelofibrosis effect

Bone Marrow Transplantation volume 26, pages 697–699 (2000)Cite this article

Abstract

A patient with idiopathic myelofibrosis (IM) in the osteosclerotic phase received an allogeneic stem cell transplant. Hemopoietic engraftment was rapid, and full donor chimerism was observed on day +70. However, a few months later, replacement of donor hemopoiesis by the patient's 20q− cell clone was observed, followed by reappearance of the blood IM features, marrow fibrosis and osteosclerosis. At 8 months from transplant donor lymphocytes were infused, which induced chronic GVHD. This resulted in normalization of the blood, with disappearance of the fibrosis and osteosclerosis, effects which persisted 20 months later. This case provides evidence for a graft-versus-disease effect in IM. Bone Marrow Transplantation (2000) 26, 697–699.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Bouroncle B, Doan CA . Myelofibrosis: clinical, hematologic and pathologic study of 110 patients Am J Med Sci 1962 243: 697–715

    Article  CAS  Google Scholar 

  2. Jacobson RJ, Salo A, Fialkow PJ . Agnogenic myeloid metaplasia: a clonal proliferation of hemopoietic stem cells with secondary myelofibrosis Blood 1978 5: 189–194

    Google Scholar 

  3. Barosi G . Myelofibrosis with myeloid metaplasia: diagnostic definition and prognostic classification for clinical studies and treatment guidelines J Clin Oncol 1999 17: 2954–2970

    Article  CAS  Google Scholar 

  4. Cervantes F, Barosi G, Demory JL et al. Myelofibrosis with myeloid metaplasia in young individuals: disease characteristics, prognostic factors and identification of risk groups Br J Haematol 1998 102: 684–690

    Article  CAS  Google Scholar 

  5. Guardiola Ph, Anderson JE, Bandini G et al. Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Société Francaise de la Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study Blood 1999 93: 2831–2838

    CAS  PubMed  Google Scholar 

  6. Kolb HJ, Mittermuller J, Clemm Ch et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients Blood 1990 76: 2462–2465

    CAS  Google Scholar 

  7. Dazzi F, Goldman J . Donor lymphocyte infusions Curr Opin Hematol 1999 6: 394–399

    Article  CAS  Google Scholar 

  8. Porter DL, Roth MS, McGarigle C et al. Induction of graft-versus-host-disease as immunotherapy for relapsed chronic myeloid leukemia New Engl J Med 1994 330: 100–106

    Article  CAS  Google Scholar 

  9. Demory JL, Dupriez B, Fenaux P et al. Cytogenetic studies and their prognostic significance in agnogenic myeloid metaplasia: a report on 47 cases Blood 1988 72: 855–859

    CAS  PubMed  Google Scholar 

  10. Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases Blood 1998 91: 756–763

    CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by grants 99/103 from the Fondo de Investigaciones Sanitarias, Spanish Ministry of Health, and FIJC-00/P-EM from the José Carreras International Leukemia Foundation.

Author information

Authors and Affiliations

  1. Department of Hematology, Institute of Hematology and Oncology, IDIBAPS, Hospital Clínic, University of Barcelona, Spain

    F Cervantes, M Rovira, A Urbano-Ispizua, M Rozman, E Carreras & E Montserrat

Authors
  1. F Cervantes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Rovira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Urbano-Ispizua
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Rozman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E Carreras
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E Montserrat
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cervantes, F., Rovira, M., Urbano-Ispizua, A. et al. Complete remission of idiopathic myelofibrosis following donor lymphocyte infusion after failure of allogeneic transplantation: demonstration of a graft-versus-myelofibrosis effect. Bone Marrow Transplant 26, 697–699 (2000). https://doi.org/10.1038/sj.bmt.1702568

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702568

Keywords

This article is cited by

Search

Advanced search

Quick links