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Epstein–Barr virus-negative high grade B cell lymphoma of donor origin developing 19 months after unrelated allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 577–579 (2000)Cite this article

Abstract

A 22-year-old man, in first complete remission of acute myelogenous leukemia, developed a high grade B cell lymphoma 19 months after an allogeneic bone marrow transplant (allo-BMT) from an HLA-identical unrelated donor. Biopsy of a cervical lymph node revealed a lymphoma that was negative for Epstein–Barr virus-encoded small nuclear RNAs (EBERs) in situhybridization. Genotypic analyses identified the lymphoma to be of donor origin, and there was no evidence of the Epstein–Barr virus (EBV) DNA in the lymphoma by Southern blot analysis. The lymphoma went into complete remission, following four courses of combination chemotherapy, but relapsed after a month and the patient died of congestive heart failure. The patient was thought to be persistently immunosuppressed 11 months after cessation of immunosuppressants, and the lymphoma was thought to be induced by one or more factors other than EBV. Bone Marrow Transplantation (2000) 26, 577–579.

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Acknowledgements

We thank Dr Seiya Hirohata (Department of Gastroenterology, Hyogo Medical Center for Adults) for ultrasonographic diagnosis, Dr Hiroshi Ueno (Department of Medicine, Hyogo Medical Center for Adults) for cardiac diagnosis and the nursing and laboratory staffs of Hyogo Medical Center for Adults. We also thank SRL for in situ hybridization and DNA analysis.

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Authors and Affiliations

  1. Hematology/Oncology Division, Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan

    H Gomyo, T Murayama, I Mizuno, T Koizumi & S Imoto

  2. Department of Pathology, Hyogo Medical Center for Adults, Akashi, Japan

    T Kizaki

  3. Hematology Division, Meitetsu Hospital, Nagoya, Japan

    K Kitaori & H Sao

  4. Hematology Division, National Cancer Center Hospital, Tokyo, Japan

    K Tobinai

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  1. H Gomyo
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Gomyo, H., Murayama, T., Kizaki, T. et al. Epstein–Barr virus-negative high grade B cell lymphoma of donor origin developing 19 months after unrelated allogeneic bone marrow transplantation. Bone Marrow Transplant 26, 577–579 (2000). https://doi.org/10.1038/sj.bmt.1702548

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  • DOI: https://doi.org/10.1038/sj.bmt.1702548

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