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Post-Transplant Complications

Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single center study of incidence, risk factors and outcome

Bone Marrow Transplantation volume 25, pages 1263–1268 (2000)Cite this article

Abstract

Non-infectious lung complications (NILC) are frequent, influencing morbidity and mortality of patients after allogeneic BMT. Although the term NILC encompasses a number of different entities, an association with GVHD has been noted for almost all of them. Our study was directed towards assessing the incidence and risk factors for developing NILC, as well as the response to treatment and long-term outcome. Forty (14.7%) out of 272 patients surviving for more than 3 months after allogeneic BMT, developed lung complications fulfilling the criteria for NILC. The evaluation was based on clinical investigation, radiologic imaging, lung function tests, broncho-alveolar lavage and biopsies. Risk factors were assessed by univariate and multiple statistical regression models, where chronic GVHD proved to be the only significant risk factor for the development of NILC (P = 0.011). In three patients NILC developed in direct association with donor lymphocyte infusions. The majority of patients responded well to treatment with corticosteroids and immunosuppressive drugs. NILC had no adverse effect on survival. The frequency of NILC was low in autologous (5%) as compared with allogeneic transplants (14.7%) but this difference was not statistically significant. Bone Marrow Transplantation (2000) 25, 1263–1268.

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Acknowledgements

We thank Dr Markus Hoegel, Birgit Hay and Margit Hafner for performing the statistic calculations.

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Authors and Affiliations

  1. Department of Haematology/Oncology, University of Ulm, Ulm, Germany

    C Duncker, S von Harsdorf, J Duyster, M Stefanic, H Heimpel, L Bergmann & D Bunjes

  2. Department of Radiotherapy, Zentralklinikum Augsburg, Augsburg, Germany

    D Dohr

  3. Department of Radiotherapy, University of Freiburg, Freiburg, Germany

    C Martini

  4. Department of Radiotherapy, University of Heidelberg, Heidelberg, Germany

    M Treiber

  5. Department of Haematology/Oncology, Medizinische Hochschule Hannover, Hannover, Germany

    B Hertenstein & J Novotny

  6. Department of Internal Medicine II, University Hospital Charité Berlin, Berlin, Germany

    R Arnold

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  1. C Duncker
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  2. D Dohr
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  3. S von Harsdorf
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  10. R Arnold
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  13. D Bunjes
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Duncker, C., Dohr, D., von Harsdorf, S. et al. Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single center study of incidence, risk factors and outcome. Bone Marrow Transplant 25, 1263–1268 (2000). https://doi.org/10.1038/sj.bmt.1702429

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