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Plasma exchange as successful treatment of thrombotic thrombocytopenic purpura post autologous bone marrow transplant in a child

Bone Marrow Transplantation volume 25, pages 679–680 (2000)Cite this article

Abstract

We describe the case of a small child with stage IV neuroblastoma who developed thrombotic thromobocytopenic purpura (TTP) post autologous bone marrow transplant. Pneumococcal sepsis may have been the cause, a previously unreported association in transplant-associated TTP. Despite the child's size (10 kg) and the severity of the disease early intensive treatment with whole blood exchange and subsequently plasma exchange with cryosupernatant proved to be rapidly effective, in contrast to previous reports on its ineffectiveness in this setting. Bone Marrow Transplantation (2000) 25, 679–680.

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Authors and Affiliations

  1. Department of Transfusion Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK

    DE Plews & ML Turner

  2. Department of Paediatric Oncology, Royal Hospital for Sick Children, Edinburgh, UK

    WHB Wallace

Authors
  1. DE Plews
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  2. ML Turner
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  3. WHB Wallace
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Plews, D., Turner, M. & Wallace, W. Plasma exchange as successful treatment of thrombotic thrombocytopenic purpura post autologous bone marrow transplant in a child. Bone Marrow Transplant 25, 679–680 (2000). https://doi.org/10.1038/sj.bmt.1702208

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  • DOI: https://doi.org/10.1038/sj.bmt.1702208

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