Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia

Bone Marrow Transplantation volume 25, pages 571–573 (2000)Cite this article

Abstract

We describe two cases of severe constrictive pericarditis arising after allogeneic BMT conditioning involving total body irradiation and melphalan to treat Philadelphia-chromosome positive ALL. Both patients required pericardectomy, resulting in marked improvement in ventricular filling. However, a degree of right-sided cardiac failure persisted in both patients secondary to restrictive cardiomyopathy. Constrictive pericarditis has not been previously described after BMT, but has been observed following thoracic radiotherapy for malignancy, usually involving a substantially higher radiation dose. Pericardial constriction and restrictive cardiomyopathy should be considered as causes of breathlessness and/or oedema occurring late after BMT. Bone Marrow Transplantation (2000) 25, 571–573.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Estey E, Thall P, Andreeff M et al. Use of granulocyte colony-stimulating factor before, during, and after fludarabine plus cytarabine induction therapy of newly diagnosed acute myelogenous leukaemia or myelodysplastic syndromes: comparison with fludarabine plus cytarabine without granulocytecolony-stimulating factor J Clin Oncol 1994 12: 671–678

    Article  CAS  Google Scholar 

  2. Jackson GH, Taylor PRA, Goff D et al. High dose ifosfamide in combination with etoposide and epirubicin in the treatment of relapsed/refractory Hodgkin's disease: a report on toxicity and efficacy Leuk Lymphoma 1998 29: 154 (Abstr.)

    Google Scholar 

  3. Fowler NO . Constrictive pericarditis: its history and current status Clin Cardiol 1995 18: 341–350

    Article  CAS  Google Scholar 

  4. Mueller XM, Tevaerarai HT, Hurni M et al. Etiologic diagnosis of pericardial disease: the value of routine tests during surgical procedures J Am Coll Surg 1997 184: 645–649

    CAS  PubMed  Google Scholar 

  5. Hirose Y, Ishida Y, Hayashida K et al. A case of radiation-induced chronic constrictive pericarditis developing 16 years after irradiation (Japanese) Jap J Nuclear Med 1993 30: 1091–1096 (Abstr.)

    CAS  Google Scholar 

  6. Kane GC, Edie RN, Mannion JD . Delayed appearance of effusive-constrictive pericarditis after radiation for Hodgkin's lymphoma Ann Intern Med 1996 124: 534–535

    Article  CAS  Google Scholar 

  7. Orzan F, Brusca A . Radiation-induced constrictive pericarditis. Associated cardiac lesions, therapy and follow-up (Italian) G Ital Cardio 1994 24: 817–823 (Abstr.)

    CAS  Google Scholar 

  8. Callaway MP, Tyrrell CJ, Williams MP, Marshall AJ . Chemotherapy induced myocardial fibrosis Clin Oncol 1994 6: 55–65

    Article  CAS  Google Scholar 

  9. Bristow MR . Anthracycline toxicity. In: Bristow MR (ed) Drug-induced Heart Disease Elsevier: Amsterdam 1980 pp 191–215

    Google Scholar 

  10. Trotter MC, Chung KC, Ochsner JL, McFadden PM . Pericardectomy for pericardial constriction Am Surg 1996 62: 304–307

    CAS  PubMed  Google Scholar 

  11. Karram T, Rinkevitch D, Markiewicz W . Poor outcome in radiation-induced constrictive pericarditis Int J Radiat Oncol Biol Phys 1993 25: 329–331

    Article  CAS  Google Scholar 

  12. Ni Y, von Sesseger LK, Turina M . Futility of pericardectomy for constrictive pericarditis? Ann Thorac Surg 1990 49: 445–448

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

    J Cavet, A Lennard, C Richardson, PRA Taylor, SJ Proctor & GH Jackson

  2. Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, UK

    A Gascoigne

  3. Department of Haematology, North Tees District General Hospital, Teeside, UK

    RD Finney

  4. Department of Radiotherapy, General Hospital, Newcastle upon Tyne, UK

    HH Lucraft

Authors
  1. J Cavet
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Lennard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Gascoigne
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. RD Finney
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. HH Lucraft
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Richardson
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. PRA Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. SJ Proctor
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. GH Jackson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cavet, J., Lennard, A., Gascoigne, A. et al. Constrictive pericarditis post allogeneic bone marrow transplant for Philadelphia-positive acute lymphoblastic leukaemia. Bone Marrow Transplant 25, 571–573 (2000). https://doi.org/10.1038/sj.bmt.1702186

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702186

Keywords

This article is cited by

Search

Advanced search

Quick links