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FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 25, pages 331–334 (2000)Cite this article

Abstract

FK506-related leukoencephalopathy has been reported to be reversible and readily treated by discontinuation or reduction of FK506. We describe two pediatric cases of FK506-related leukoencephalopathy following allogeneic bone marrow transplantation, which could not be readily controlled. These cases show that FK506-related leukoencephalopathy is not always reversible, and patients may develop epilepsy. Bone Marrow Transplantation (2000) 25, 331–334.

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References

  1. Freise CE, Rowley H, Lake J et al. Similar clinical presentation of neurotoxicity following FK506 and cyclosporine in a liver transplant recipient Transplant Proc 1991 23: 3173–3174

    CAS  PubMed  Google Scholar 

  2. Small SL, Fukui MB, Bramblett GT, Eidelman BH . Immunosuppression-induced leukoencephalopathy from tacrolimus (FK506) Ann Neurol 1996 40: 575–580

    Article  CAS  Google Scholar 

  3. Thyagarajan GK, Cobanoglu A, Johnston W . FK506-induced fulminant leukoencephalopathy after single-lung transplantation Ann Thorac Surg 1997 64: 1461–1464

    Article  CAS  Google Scholar 

  4. Shutter LA, Green JP, Newman NJ et al. Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation Neurology 1993 43: 2417–2418

    Article  CAS  Google Scholar 

  5. Pizzolato GP, Sztajzel R, Burkhardt K et al. Cerebral vasculitis during FK506 treatment in liver transplant patient Neurology 1998 50: 1154–1157

    Article  CAS  Google Scholar 

  6. Hinchey J, Chaves C, Appignani B et al. A reversible posterior leukoencephalopathy syndrome New Engl J Med 1996 334: 494–500

    Article  CAS  Google Scholar 

  7. Steg RE, Kessinger A, Wszolek ZK . Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation Bone Marrow Transplant 1999 23: 959–962

    Article  CAS  Google Scholar 

  8. Pettitt AR, Clark RE . Thrombotic microangiopathy following bone marrow transplantation Bone Marrow Transplant 1994 14: 495–504

    CAS  PubMed  Google Scholar 

  9. Iwasaki Y, Sako K, Ohara Y et al. Subacute panencephalitis associated with chronic graft-versus-host disease Acta Neuropathol 1993 85: 566–572

    CAS  PubMed  Google Scholar 

  10. Sharkey J, Butcher SP . Immunophilins mediate the neuroprotective effect of FK506 in focal cerebral ischaemia Nature 1994 371: 336–339

    Article  CAS  Google Scholar 

  11. Steiner JP, Dawson TM, Fotuhi M et al. High brain densities of the immunophilin FKBP colocalized with calcineurin Nature 1992 358: 584–587

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan

    A Misawa, Y Takeuchi, S Hibi, S Todo & T Sawada

  2. Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan

    S Imashuku

Authors
  1. A Misawa
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  2. Y Takeuchi
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  3. S Hibi
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  4. S Todo
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  5. S Imashuku
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  6. T Sawada
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Misawa, A., Takeuchi, Y., Hibi, S. et al. FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 331–334 (2000). https://doi.org/10.1038/sj.bmt.1702143

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  • DOI: https://doi.org/10.1038/sj.bmt.1702143

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