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Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes

Bone Marrow Transplantation volume 24, pages 1043–1051 (1999)Cite this article

Abstract

Patients with recurrent leukemia after an allogeneic hematopoietic stem cell transplant may be treated with donor lymphocyte infusions (DLI). The transfusion of lymphocytes from the original hematopoietic stem cell donor induces remission in approximately one third of relapsed AML cases and 80% of relapsed CML. DLI may be complicated by delayed and sometimes lethal graft-versus-host disease (GVHD). In an attempt to avoid this complication, several centers have initiated DLI trials in which the infused lymphocytes carry a suicide gene, herpes simplex thymidine kinase (HStk), which confers sensitivity to ganciclovir (GCV). In the event of severe GVHD, administration of GCV should terminate or ameliorate GVHD.

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Authors and Affiliations

  1. Northwestern University School of Medicine, Robert H Lurie Cancer Center, Chicago, IL, USA

    RK Burt & AE Traynor

  2. Medical College of Wisconsin, Milwaukee, WI, USA

    WR Drobyski

  3. Human Gene Therapy Research Institute, Des Moines, IA, USA

    CJLink Jr

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  1. RK Burt
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  2. WR Drobyski
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  3. AE Traynor
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Burt, R., Drobyski, W., Traynor, A. et al. Herpes simplex thymidine kinase (HStk) transgenic donor lymphocytes. Bone Marrow Transplant 24, 1043–1051 (1999). https://doi.org/10.1038/sj.bmt.1702020

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  • DOI: https://doi.org/10.1038/sj.bmt.1702020

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