Abstract
We report the case of a 10-year-old boy with congenital pure red cell aplasia (Diamond–Blackfan anaemia) who received an allogeneic bone marrow transplant (BMT) from his HLA-identical sister. The transplant was complicated by moderate veno-occlusive disease (VOD). Despite cytogenetic evidence of complete donor haemopoietic stem cell engraftment there was selective failure of red cell engraftment and he remains red cell transfusion-dependent. This is the first case of a stem cell transplant failing to correct the defect in this condition despite engraftment.
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Wynn, R., Grainger, J., Carr, T. et al. Failure of allogeneic bone marrow transplantation to correct Diamond–Blackfan anaemia despite haemopoietic stem cell engraftment. Bone Marrow Transplant 24, 803–805 (1999). https://doi.org/10.1038/sj.bmt.1701982
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DOI: https://doi.org/10.1038/sj.bmt.1701982
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