Miscellaneous Complications

Neurological complications after stem cell transplantation in childhood

Abstract

We analyzed the incidence of neurological complications in 77 patients receiving stem cell transplantation (SCT), and 12 patients (15.8%) had the following symptoms: convulsions, intracranial hemorrhage, and leukoencephalopathy. Although statistically not significant, neurological complications were seen more frequently in patients after allogeneic transplantation, and in those with acute graft-versus-host disease (GVHD) exceeding grade II. The most significant risk factor for neurological complications was identified as unrelated donor allogenic transplantation (P = 0.016). Complications were categorized into three groups, based on time of onset and symptoms: (1) convulsions during the conditioning period, (2) intracranial hemorrhage during the period of granulocyte recovery, and (3) leukoencephalopathy at around 2 months after SCT. We propose awareness of the risks of neurological complications in each period after SCT so that immediate and effective treatment of patients can be instigated.

Author information

Affiliations

Authors

Corresponding author

Correspondence to A Iguchi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Iguchi, A., Kobayashi, R., Yoshida, M. et al. Neurological complications after stem cell transplantation in childhood. Bone Marrow Transplant 24, 647–652 (1999). https://doi.org/10.1038/sj.bmt.1701969

Download citation

Keywords

  • stem cell transplantation (SCT)
  • neurological complication
  • convulsion
  • intracranial hemorrhage
  • leukoencephalopathy

Further reading