Miscellaneous Complications

Neurological complications after stem cell transplantation in childhood


We analyzed the incidence of neurological complications in 77 patients receiving stem cell transplantation (SCT), and 12 patients (15.8%) had the following symptoms: convulsions, intracranial hemorrhage, and leukoencephalopathy. Although statistically not significant, neurological complications were seen more frequently in patients after allogeneic transplantation, and in those with acute graft-versus-host disease (GVHD) exceeding grade II. The most significant risk factor for neurological complications was identified as unrelated donor allogenic transplantation (P = 0.016). Complications were categorized into three groups, based on time of onset and symptoms: (1) convulsions during the conditioning period, (2) intracranial hemorrhage during the period of granulocyte recovery, and (3) leukoencephalopathy at around 2 months after SCT. We propose awareness of the risks of neurological complications in each period after SCT so that immediate and effective treatment of patients can be instigated.

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Correspondence to A Iguchi.

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Iguchi, A., Kobayashi, R., Yoshida, M. et al. Neurological complications after stem cell transplantation in childhood. Bone Marrow Transplant 24, 647–652 (1999). https://doi.org/10.1038/sj.bmt.1701969

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  • stem cell transplantation (SCT)
  • neurological complication
  • convulsion
  • intracranial hemorrhage
  • leukoencephalopathy

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