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Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal

Bone Marrow Transplantation volume 23, pages 99–101 (1999)Cite this article

Abstract

GVHD is one of the most frequent complications of BMT and recently nephrotic syndrome (NS) has been described as a manifestation of chronic GVHD. Here, we present an AA patient who developed NS 1 year after BMT when cyclosporine was stopped. Renal biopsy showed focal sclerosis associated with membranous deposits. He also had other clinical manifestations of chronic GVHD: sicca-like syndrome and colestasis. After 15 days of CsA therapy, he experienced a remarkable improvement in the NS and GVHD as a whole. We comment on immunological mechanisms that could be involved in the pathogenesis of this manifestation.

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Authors and Affiliations

  1. Department of Hematology, EPM/UNIFESP, São Paulo, Brazil

    JSR Oliveira, D Bahia & J Kerbauy

  2. Department of Pathology, EPM/UNIFESP, São Paulo, Brazil

    M Franco

  3. Department of Nephrology, EPM/UNIFESP, São Paulo, Brazil

    C Balda & S Stella

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  1. JSR Oliveira
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  2. D Bahia
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  3. M Franco
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  4. C Balda
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  5. S Stella
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  6. J Kerbauy
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Oliveira, J., Bahia, D., Franco, M. et al. Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal. Bone Marrow Transplant 23, 99–101 (1999). https://doi.org/10.1038/sj.bmt.1701527

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  • DOI: https://doi.org/10.1038/sj.bmt.1701527

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