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A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation

Bone Marrow Transplantation volume 22, pages 307–309 (1998)Cite this article

Abstract

A fatal case of EBV-associated lymphoproliferative disorder arising after a CD34-selected autologous peripheral blood stem cell transplant is reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accessory cell depletion associated with the CD34+ cell purification and it is recommended that a source of autologous T cells is stored before transplantation to be used if a severe opportunistic infection or EBV lymphoma arises post-transplantation.

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Authors and Affiliations

  1. Department of Haematology, University College London Hospitals, London, UK

    AJ Peniket, AR Perry, CD Williams, MJ Watts, AH Goldstone & DC Linch

  2. Department of Histology, University College London Hospitals, London, UK

    A MacMillan

  3. Department of Haematology, Mount Vernon Hospital, Northwood, UK

    PG Isaacson

Authors
  1. AJ Peniket
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  2. AR Perry
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  3. CD Williams
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  4. A MacMillan
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  5. MJ Watts
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  6. PG Isaacson
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  7. AH Goldstone
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  8. DC Linch
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Peniket, A., Perry, A., Williams, C. et al. A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation. Bone Marrow Transplant 22, 307–309 (1998). https://doi.org/10.1038/sj.bmt.1701335

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  • DOI: https://doi.org/10.1038/sj.bmt.1701335

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