Abstract
A patient with primary Sjögren’s syndrome developed massive gland enlargement and was diagnosed a MALT-type lymphoma stage IIA. After initial radiotherapy the patient relapsed with high grade immunoblastic lymphoma. Chemotherapy led to remission of the lymphoma and improvement of the autoimmune disease. A peripheral blood stem cell harvest was performed. However, subsequent to standard chemotherapy the patient experienced an exacerbation of arthralgia and vasculitis while his lymphoma remained in partial remission. With additional chemotherapy and steroid treatment complete remission of the lymphoma and autoimmune disease was achieved and high-dose chemotherapy followed by PBPCT with an unmanipulated graft was performed. Engraftment was prompt with no signs of active autoimmune disease after the transplantation. Two months later, signs of autoimmune disease slowly recurred. Steroid treatment improved this, but the patient remained steroid-dependent and later died from therapy-resistant Pneumocystis carinii pneumonia while the lymphoma remained in complete remission. In this patient with systemic Sjögren’s disease, PBPCT completely controlled the aggressive lymphoma but was not permanently effective for the autoimmune disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rösler, W., Manger, B., Repp, R. et al. Autologous PBPCT in a patient with lymphoma and Sjögren’s syndrome: complete remission of lymphoma without control of the autoimmune disease. Bone Marrow Transplant 22, 211–213 (1998). https://doi.org/10.1038/sj.bmt.1701312
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701312
Keywords
This article is cited by
-
Allogeneic haematopoietic stem cell transplantation for severe autoimmune diseases: great expectations but controversial evidence
Bone Marrow Transplantation (2006)
-
Clinically demonstrable anti-autoimmunity mediated by allogeneic immune cells favorably affects outcome after stem cell transplantation in human autoimmune diseases
Bone Marrow Transplantation (2002)
-
Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: Getting closer to a cure?
International Journal of Hematology (2002)
-
Crohn’s disease complicated by relapsed extranodal Hodgkin’s lymphoma: prolonged complete remission after unmanipulated PBPC autotransplant
Bone Marrow Transplantation (2000)
-
Stem cell transplantation for treatment of severe autoimmune diseases: current status and future perspectives
Bone Marrow Transplantation (2000)