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Cord Blood Stem Cells

Successful salvage using mismatched umbilical cord blood transplant in an adult with recurrent acute myelogenous leukemia failing autologous peripheral blood progenitor cell transplant: a case history and review

Bone Marrow Transplantation volume 21, pages 1197–1200 (1998)Cite this article

Abstract

We report a 26-year-old female with AML, FAB classification M5 who was initially treated with induction therapy consisting of idarubicin and cytarabine followed by high-dose cytarabine and autologous peripheral blood progenitor cell (PBPC) transplant for consolidation. The patient remained in remission for 1 month post-PBPC transplant, when relapse was noted. Reinduction therapy with idarubicin, cytarabine and etoposide was unsuccessful, and the patient underwent an unrelated, two-antigen mismatched umbilical cord blood (UCB) transplant for salvage after melphalan plus total body irradiation. Complications post transplant included veno-occlusive disease, delayed engraftment, and acute grade III graft-versus-host disease (GVHD). The patient remains in remission 1 year post transplant. This study demonstrates the salvage capability of UCB transplantation for refractory leukemia and its potential use in adult patients.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA

    VG Gian, JS Moreb, FM Weeks & JR Wingard

  2. Division of Hematology/Oncology, Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA

    A Abdel-Mageed

  3. Department of Pathology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA

    JC Scornick

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  1. VG Gian
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  2. JS Moreb
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  3. A Abdel-Mageed
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  4. FM Weeks
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  5. JC Scornick
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  6. JR Wingard
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Gian, V., Moreb, J., Abdel-Mageed, A. et al. Successful salvage using mismatched umbilical cord blood transplant in an adult with recurrent acute myelogenous leukemia failing autologous peripheral blood progenitor cell transplant: a case history and review. Bone Marrow Transplant 21, 1197–1200 (1998). https://doi.org/10.1038/sj.bmt.1701249

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  • DOI: https://doi.org/10.1038/sj.bmt.1701249

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