Abstract
The performance of two Aspergillus antigenemia systems, the sandwich enzyme-linked immunosorbent assay (ELISA), Platelia Aspergillus test, and the latex agglutination (LA), Pastorex Aspergillus test, in the diagnosis of invasive aspergillosis were compared by testing 364 serum samples from 22 bone marrow transplant (BMT) recipients. Sensitivity and specificity for the ELISA test were 60% and 82% respectively, vs 40% and 94% for the LA test. In the two patients found positive with both methods, the ELISA test became positive earlier than the LA test or remained positive after the LA test had become negative. These results encourage further evaluation of the Platelia Aspergillus test, to assess its role in the management of invasive aspergillosis in BMT patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Machetti, M., Feasi, M., Mordini, N. et al. Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipients. Bone Marrow Transplant 21, 917–921 (1998). https://doi.org/10.1038/sj.bmt.1701206
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701206
Keywords
This article is cited by
-
Die serologische Diagnostik von Pilzinfektionen
Wiener Medizinische Wochenschrift (2007)
-
Strategies to enhance immune function in hematopoietic transplantation recipients who have fungal infections
Bone Marrow Transplantation (2006)
-
The contribution of galactomannan detection in the diagnosis of invasive aspergillosis in bone marrow transplant recipients
Mycopathologia (2005)
-
Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies
Annals of Hematology (2003)
-
Aspergillus infections in allogeneic stem cell transplant recipients: have we made any progress?
Bone Marrow Transplantation (2002)