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Donor lymphocyte transfusion for the treatment of Epstein–Barr virus-associated lymphoproliferative disorder of the brain

Bone Marrow Transplantation volume 21, pages 1155–1158 (1998)Cite this article

Abstract

EBV-associated lymphoproliferative disorder (LPD) is a rare but serious complication in marrow transplant recipients. A 31-year-old Japanese woman in the second chronic phase of CML received an allogeneic BMT from her HLA 2-locus-incompatible 62-year-old father. Around day +200, she developed EBV-LPD of the right parieto-temporal lobe which caused slowly progressive left hemiparesis. Two courses of donor lymphocyte transfusions (DLT) of 106 CD3+ T cells/kg of body weight failed to suppress her central nervous system (CNS) EBV-LPD. The patient died of recurrent blastic crisis of CML. This case suggests that DLT may be ineffective for the treatment of CNS EBV-LPD.

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Authors and Affiliations

  1. Department of Hematology, Hara Sanshin General Hospital, Fukuoka, Japan

    K Nagafuji, T Eto & S Hayashi

  2. First Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan

    K Oshima

  3. Second Department of Internal Medicine, School of Medicine, Okayama University, Okayama, Japan

    Y Maeda

  4. First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    H Gondo & Y Niho

  5. Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    T Inamura

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  1. K Nagafuji
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  2. T Eto
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  3. S Hayashi
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  4. K Oshima
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  5. Y Maeda
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  6. H Gondo
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  7. T Inamura
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  8. Y Niho
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Nagafuji, K., Eto, T., Hayashi, S. et al. Donor lymphocyte transfusion for the treatment of Epstein–Barr virus-associated lymphoproliferative disorder of the brain. Bone Marrow Transplant 21, 1155–1158 (1998). https://doi.org/10.1038/sj.bmt.1701205

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  • DOI: https://doi.org/10.1038/sj.bmt.1701205

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