Abstract
Bone marrow (BM) histiocystosis in association with the administration of granulocyte–macrophage colony- stimulating factor (GM-CSF) is a rare phenomenon with few published cases. We report two cases of BM histiocystosis in patients with Hodgkin’s disease treated with GM-CSF after autologous bone marrow transplantation. Both patients also developed clinical features of capillary leak syndrome, another rare complication of GM-CSF administration. GM-CSF-induced histiocystosis should now be considered in the differential diagnosis of delayed engraftment post-autotransplant.
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Al-Homaidhi, A., Prince, H., Al-Zahrani, H. et al. Granulocyte–macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature. Bone Marrow Transplant 21, 209–214 (1998). https://doi.org/10.1038/sj.bmt.1701036
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DOI: https://doi.org/10.1038/sj.bmt.1701036
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