Abstract
Phialophora is a dematiaceous fungus isolated from soil and wood. Human infections including chromoblastomycosis, mycotic keratitis, cutaneous infections, and prosthetic valve endocarditis have been reported. We report a case of fatal hemorrhage due to Phialophora verrucosa in a patient with prolonged neutropenia undergoing autologous bone marrow transplant (BMT) for acute myelogenous leukemia (AML). Bacterial infections complicated induction and consolidation chemotherapies. Liposomal amphotericin B (LAMB) was given from day +33 to day +72 for febrile neutropenia. Death occurred on day +74 due to tracheal hemorrhage. Autopsy revealed granulation tissue on the posterior wall of the trachea with fungal hyphae on histopathology; the tissue grew Phialophora verrucosa. In vitro susceptibility studies revealed a minimum inhibitory concentration to AmB of 0.1 μ g/ml. This represents the first reported case of invasive P. verrucosa in a BMT patient leading to fatal hemorrhage, despite large cumulative doses of LAMB to which the organism remained susceptible.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lundstrom, T., Fairfax, M., Dugan, M. et al. Phialophora verrucosa infection in a BMT patient. Bone Marrow Transplant 20, 789–791 (1997). https://doi.org/10.1038/sj.bmt.1700969
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1700969
Keywords
This article is cited by
-
Effectiveness of voriconazole and corneal cross-linking on Phialophora verrucosa keratitis: a case report
Journal of Medical Case Reports (2018)
-
1,10-Phenanthroline Inhibits the Metallopeptidase Secreted by Phialophora verrucosa and Modulates its Growth, Morphology and Differentiation
Mycopathologia (2015)
-
Recalcitrant Primary Subcutaneous Phaeohyphomycosis Due to Phialophora verrucosa
Mycopathologia (2013)