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CML blast crisis resulting in biliary obstruction following BMT

Bone Marrow Transplantation volume 19, pages 853–854 (1997)Cite this article

Abstract

Allogeneic BMT is the treatment of choice for various hematologic malignancies. Despite careful patient scrutiny, a large number of patients experience significant morbidity and mortality due to procedure-related toxicity. Hepatobiliary toxicity presenting as biliary cholestasis, due to the preparative regimen (ie veno- occlusive disease), supportive pharmaceuticals, and/or GVHD have been implicated. We report a unique cause of cholestasis in a patient undergoing BMT for CML. The cholestasis was found to be secondary to relapsed leukemia, which resulted in a granulocytic sarcoma obstructing the biliary ductal system.

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Authors and Affiliations

  1. Division of Hematology/Oncology, University of Louisville, KY, USA

    DR Fleming

  2. Department of Pathology, University of Louisville, KY, USA

    SP Slone

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  1. DR Fleming
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  2. SP Slone
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Fleming, D., Slone, S. CML blast crisis resulting in biliary obstruction following BMT. Bone Marrow Transplant 19, 853–854 (1997). https://doi.org/10.1038/sj.bmt.1700748

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  • DOI: https://doi.org/10.1038/sj.bmt.1700748

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