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Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir

Bone Marrow Transplantation volume 19, pages 503–505 (1997)Cite this article

Abstract

After 582 allogeneic bone marrow transplants, we have encountered four patients (0.7%) who developed transient unilateral or bilateral sixth nerve palsies. Three of the four patients also had bilateral ptosis. These signs resolved 24–48 h after cyclosporin and ganciclovir were discontinued. One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity. We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.

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Authors and Affiliations

  1. Department of Neurology, City of Hope National Medical Center, Duarte, CA, USA

    H Openshaw & NE Slatkin

  2. Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA, USA

    E Smith

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  1. H Openshaw
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  2. NE Slatkin
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  3. E Smith
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Openshaw, H., Slatkin, N. & Smith, E. Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir. Bone Marrow Transplant 19, 503–505 (1997). https://doi.org/10.1038/sj.bmt.1700679

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  • DOI: https://doi.org/10.1038/sj.bmt.1700679

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