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Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur

Abstract

Objective:

To describe the vitamin D status of women living in two Asian cities, – Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D.

Design:

Cross-sectional.

Setting:

Jakarta, Indonesia and Kuala Lumpur, Malaysia.

Participants:

A convenience sample of 504 non-pregnant women 18–40 years.

Main measures:

Plasma 25-hydroxyvitamin D and PTH.

Results:

The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (<17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (<50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were −0.18 (different from 0; P=0.003) and −0.01 (P=0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P=0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d.

Conclusion:

On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.

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Acknowledgements

This work was supported by a research grant from Fonterra Brands Limited.

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Correspondence to C M Skeaff.

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Green, T., Skeaff, C., Rockell, J. et al. Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur. Eur J Clin Nutr 62, 373–378 (2008). https://doi.org/10.1038/sj.ejcn.1602696

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602696

Keywords

  • vitamin D
  • parathyroid hormone
  • women
  • survey
  • Jakarta
  • Kuala Lumpur

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