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Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil

European Journal of Clinical Nutrition volume 61, pages 434–437 (2007)Cite this article

Abstract

The fetal origins hypothesis states that nutritional deprivation in utero affects fetal development and contributes to the incidence of diseases associated with the metabolic syndrome in later life. This study investigated whether haemoglobin (Hb) A1c, an indicator of blood glucose, varied among healthy male adolescents according to their fetal growth rate, in a middle-income setting. Participants were men aged 18 years, belonging to the 1982 Pelotas birth cohort. Complete data, including gestational age and Hb A1c at age 18 years, were available for 197 individuals. There was an inverse association between mean Hb A1c and birthweight for the gestational age, but not birthweight alone. The association remained significant after adjustment for family income and mother's education, as well as for body mass index at 18 years (P for trend=0.01 and 0.03, respectively).

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Authors and Affiliations

  1. Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil

    A Nazmi, C G Victora & R C Lima

  2. Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, London, UK

    S R Huttly

  3. Department of Microbiology and Parasitology, Federal University of Pelotas, Pelotas, RS, Brazil

    P R Post

  4. Brazilian Army, Tuiuti Regiment- 8th Motorised Infantry Brigade, Pelotas, RS, Brazil

    J W L Elizalde & B M C Gerson

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  1. A Nazmi
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  2. S R Huttly
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  3. C G Victora
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  4. R C Lima
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  5. P R Post
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  6. J W L Elizalde
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  7. B M C Gerson
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Correspondence to A Nazmi.

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Nazmi, A., Huttly, S., Victora, C. et al. Hb A1c in relation to intrauterine growth among male adolescents in southern Brazil. Eur J Clin Nutr 61, 434–437 (2007). https://doi.org/10.1038/sj.ejcn.1602535

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602535

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