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Perceived food intolerance in subjects with irritable bowel syndrome – etiology, prevalence and consequences

Abstract

Objectives:

This study estimates the prevalence of perceived food intolerance and its consequences in subjects with irritable bowel syndrome (IBS), evaluates the utility of common tests for food intolerance, studies the relation between perceived food intolerance and other disorders, and discusses the etiology.

Design:

Cross-sectional study.

Setting:

National health survey.

Subjects:

A selection of the population (n=11078) in Oppland county, Norway, was invited to a health screening, and a sample of subjects with IBS were included in the study.

Interventions:

A medical history of food intolerance, musculoskeletal pain, mood disorders and abdominal complaints was taken, and tests were performed for food allergy and malabsorption. A dietician evaluated the dietary habits of the subjects.

Results:

Out of 4622 subjects with adequately filled-in questionnaires, 84 were included in the study, 59 (70%) had symptoms related to intake of food, 62% limited or excluded food items from the diet and 12% had an inadequate diet. The mean numbers of food items related to symptoms and the number of foods limited or excluded from the diet were 4.8 and 2.5, respectively. There were no associations between the tests for food allergy and malabsorption and perceived food intolerance. Perceived food intolerance was unrelated to musculoskeletal pain and mood disorders.

Conclusions:

Perceived food intolerance is a common problem with significant nutritional consequences in a population with IBS. The uselessness of current antibody tests and tests for malabsorption and the lack of correlation to psychiatric co-morbidity make the etiology obscure.

Sponsorship:

Innlandet Hospital Health Authority, Norway.

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Acknowledgements

We wish to thank the Norwegian Institute of Public Health for inviting us to participate in the health study and for pleasant collaboration, Fürst Medisinsk Laboratorium, Søren Bulls vei 25, 1051 Oslo, for permission to publish the results from the analyses of food antibodies, and Innlandet Hospital Health Authority, Norway for grants.

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Correspondence to P G Farup.

Additional information

Guarantor: PG Farup.

Contributors: KWM wrote the protocol that was designed in collaboration by all the authors. KWM was the dietician responsible for the patients and collected all the information about dietary habits; POV was the physician responsible for the patients and collected the medical information. KWM and POV were responsible for the clean data file. PGF performed the statistical analyses and wrote the paper, which was critically revised and approved by all the authors.

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Monsbakken, K., Vandvik, P. & Farup, P. Perceived food intolerance in subjects with irritable bowel syndrome – etiology, prevalence and consequences. Eur J Clin Nutr 60, 667–672 (2006). https://doi.org/10.1038/sj.ejcn.1602367

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602367

Keywords

  • anxiety
  • cross-sectional study
  • depression
  • food hypersensitivity
  • functional gastrointestinal disorders
  • mood disorders

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