Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Communication
  • Published:

Newborn thyrotropin screening confirms iodine deficiency in Latvia

Abstract

Objective and setting:

The national neonatal thyrotropin (TSH) screening data for 2000–2002 were analysed to assess the extent and severity of iodine deficiency in Latvia.

Results:

Elevated newborn TSH (>5 mIU/l) decreased from 16.5 to 10.4% and 8.4% in 2000, 2001 and 2002, respectively. For each year and in all regions, the prevalence of elevated newborn TSH was above the cut-off level indicative for a public health problem. A positive correlation (r=0.82, P<0.05) existed between elevated newborn TSH and low urinary iodine excretion among a nationwide sample of school children in 2000.

Conclusion:

Latvia is iodine deficient, putting each new generation at risk of preventable brain damage.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  • Altman DG, Machin D, Bryant TN, Gardner MJ (eds) (2003). Statistics with Confidence, 2nd edn. BMJ Books: Bristol.

    Google Scholar 

  • Bleichrodt N, Born M-Ph (1994). A meta-analysis of research on iodine and its relationship to cognitive development. In: Stanbury JB (ed). The Damaged Brain of Iodine Deficiency: Cognitive, Behavioral, Neuromotor and Educative Aspects. Cognizant Communication Corporation: New York, pp 195–200.

    Google Scholar 

  • Delange F (1998). Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. Thyroid 8, 1185–1192.

    Article  CAS  Google Scholar 

  • Delange F (2001). Iodine deficiency as a cause of brain damage. Postgrad Med J 77, 217–220.

    Article  CAS  Google Scholar 

  • Maberly GF, Haxton DP, van der Haar F (2003). Iodine deficiency: consequences and progress toward elimination. Fd Nutr Bull 24 (Suppl), S89–S96.

    Google Scholar 

  • McElduff A, McElduff P, Gunton JE, Hams G, Wiley V, Wilcken BM (2002). Neonatal thyroid-stimulating hormone concentrations in northern Sydney: further indications of mild iodine deficiency? Med J Australia 176, 317–320.

    PubMed  Google Scholar 

  • Morreale de Escobar G (2001). The role of thyroid hormone in fetal neurodevelopment. J Pediat Endocrinol Metab 14, 1453–1462.

    Google Scholar 

  • Selga G, Sauka M, Gerasimov G (2001). Status of iodine deficiency in Latvia reconsidered: results of a nation-wide survey of 587 schoolchildren in 2000. IDD Newslett 16, 54.

    Google Scholar 

  • Stanbury JB (ed) (1994). The Damaged Brain of Iodine Deficiency. Cognitive, Behavioral, Neuromotor and Educative Aspects. Cognizant Communication Corporation: New York.

    Google Scholar 

  • Tylek-Lemanska D, Rybakowa M, Kumorowicz-Kopiec M, Dziatkowiak H, Ratajczak R (2003). Iodine deficiency disorders incidence in neonates based on the experience with mass screening for congenital hypothyroidism in southeast Poland in the years 1985–2000. J Endocrinol Invest 26 (Suppl 2), S32–S38.

    Google Scholar 

  • UNICEF (2002). United Nations Special Session on Children. A World Fit for Children. UNICEF: New York.

  • UNICEF-WHO Joint Committee on Health Policy (1994). World Summit for Children – Mid-decade Goal: Iodine Deficiency Disorders Special session; 27–28 January 1994; Geneva. World Health Organization: Geneva. doc JCHPSS/94/2.7.

  • WHO/UNICEF/ICCIDD (2001). Assessment of Iodine Deficiency Disorders and Monitoring their Elimination. A Guide for Programamme Managers. World Health Organization: Geneva, pub WHO/NHD/01.1.

  • Zimmermann MB, Aeberli I, Torresani T, Buergi H (2005). Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children: A 5-y prospective national study. Am J Clin Nutr 82, 388–392.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are grateful to the Ministry of Health of Latvia, in particular Dr Inga Smate, Head of Epidemiological Safety and Nutrition Department and Dr Lelde Vancovica, Head of Mother and Child Health Department for ensuring access to the data in the Ministry of Health and State Statistical Agency. RH Gyurjyan received partial funding from the Transcultural Fund, Emory University.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F van der Haar.

Additional information

Guarantor: F van der Haar.

Contributors: RL and PV collected data; RL, RHG, and FvdH reviewed the data; RHG and FvdH analysed the data. All authors contributed to the preparation of the report.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gyurjyan, R., Lugovska, R., Vevere, P. et al. Newborn thyrotropin screening confirms iodine deficiency in Latvia. Eur J Clin Nutr 60, 688–690 (2006). https://doi.org/10.1038/sj.ejcn.1602364

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ejcn.1602364

Keywords

This article is cited by

Search

Quick links