Abstract
Objective: Assessment of the physiological effects of a diet rich in phosphorus in young women.
Design: Control period I—commercial basic diet containing 1700 mg P and 1500 mg Ca/day for 4 weeks. Supplementation period—a 6 week high-phosphorus period of 3008 mg P and 1995 mg Ca/day. Control period II—4 weeks washout with basic diet as in period I.
Setting: Institute of Nutritional Science, Friedrich Schiller University, Jena.
Subjects: Ten healthy women, aged 20–30 y.
Interventions: Orange juice and tablets, containing supplements of Ca5(PO4)3OH and NaH2PO4, totalling 1436 mg elemental phosphorus per day.
Results: There was an increase of 10.7±13.7 pg/ml in serum PTH, a decrease of 0.6±0.6 ng/ml in serum osteocalcin, an increase of 73.6±136.6 nmol/mmol creatinine in urinary pyridinoline and of 19.3±36.0 nmol/mmol creatinine in urinary deoxypyridinoline, and a decrease of 2.6±9.3 mg/l in urinary microalbumin. All changes were insignificant. There were no changes in serum levels of Ca, PO4 or Zn, in serum concentration of 1,25-(OH)2D3, and in urinary β-2-microglobulin excretion. Phosphorus supplementation caused intestinal distress, soft stools or mild diarrhoea.
Conclusions: In spite of a high phosphorus supplementation no significant changes in bone-related hormones, pyridinium crosslinks as markers of bone resorption and parameters of renal function in young women were found.
European Journal of Clinical Nutrition (2001) 55, 153–161
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Grimm, M., Müller, A., Hein, G. et al. High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women. Eur J Clin Nutr 55, 153–161 (2001). https://doi.org/10.1038/sj.ejcn.1601131
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DOI: https://doi.org/10.1038/sj.ejcn.1601131
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