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From Tpr-Met to Met, tumorigenesis and tubes

Oncogene volume 26, pages 1276–1285 (2007)Cite this article

Abstract

The receptor for hepatocyte growth factor (HGF)/scatter factor (SF), Met, controls a program of invasive epithelial growth through the coordination of cell proliferation and survival, cell migration and epithelial morphogenesis. This process is important during embryogenesis and for organ regeneration in the adult. However, when deregulated the HGF/SF-Met signaling axis contributes to tumorigenesis and metastasis. Studies on the oncogenic activation of the Met receptor have shed light on the molecular mechanisms underlying the oncogenic activation of receptor tyrosine kinase (RTKs). More than a decade ago, work on the Met related oncogene, Tpr-Met, revealed the mechanism for activation of RTK-derived oncogenes generated following chromosomal translocation. More recently, studies on the mechanisms of downregulation of the Met RTK highlight a role for loss of downregulation in RTK oncogenic activation.

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Authors and Affiliations

  1. Department of Biochemistry, Molecular Oncology Group, McGill University Health Center, McGill University, Montréal, Québec, Canada

    P Peschard & M Park

  2. Department of Medicine, McGill University, Molecular Oncology Group, McGill University Health Center, Montréal, Québec, Canada

    M Park

  3. Department of Oncology, McGill University, Molecular Oncology Group, McGill University Health Center, Montréal, Québec, Canada

    M Park

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  1. P Peschard
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  2. M Park
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Correspondence to M Park.

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Peschard, P., Park, M. From Tpr-Met to Met, tumorigenesis and tubes. Oncogene 26, 1276–1285 (2007). https://doi.org/10.1038/sj.onc.1210201

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