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pRb2/p130: a new candidate for retinoblastoma tumor formation

Oncogene volume 25, pages 5333–5340 (2006)Cite this article

Abstract

Retinoblastoma is the most common primary intraocular tumor in childhood. Mutations in both the alleles of the RB1 gene represent the causative agent for the tumor to occur. It is becoming evident that, although these alterations represent key events in the genesis of retinoblastoma, they are not sufficient per se for the tumor to develop, and other additional genetic or epigenetic alterations must occur. A supportive role in the genesis of retinoblastoma has recently been proposed for the RB1-related gene RB2/p130. Additionally, several other genetic alterations involving different chromosomes have been described as relevant in the tumorigenic process. In this review we will analyse current knowledge about the molecular mechanisms involved in retinoblastoma, paying particular attention to the mechanisms of inactivation of the biological function of the retinoblastoma family of proteins.

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References

  • Adams PD, Sellers WR, Sharma SK, Wu AD, Nalin CM, Kaelin Jr WR . (1996). Mol Cell Biol 16: 6623–6633.

  • Arheden K, Tommerup N, Mandhal H, Heim S, Winther J, Jensen OA et al. (1988). Cytogenet Cell Genet 48: 174–177.

  • Bellan C, De Falco G, Tosi GM, Lazzi S, Ferrari F, Morbini G et al. (2002). Invest Ophthalmol Vis Sci 43: 3602–3608.

  • Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T . (1998). Nature 391: 597–601.

  • Bremner R, Du DC, Connolly-Wilson MJ, Bridge P, Ahmad KF, Mostachfi H et al. (1997). Am J Hum Genet 61: 556–570.

  • Buyse IM, Shao G, Huang S . (1995). Proc Natl Acad Sci USA 92: 4467–4471.

  • Cano J, Oliveros O, Yunis E . (1994). Cancer Genet Cytogenet 76: 112–115.

  • Chen CF, Chen Y, Dai K, Chen PL, Riley DJ, Lee WH . (1996). Mol Cell Biol 16: 4691–4699.

  • Chen CS, Bejcek BE, Kersey JH . (1995). Cytogenet Cell Genet 69: 260–265.

  • Chen D, Pajovic S, Duckett A, Brown VD, Squire JA, Gallie BL . (2002). Cancer Res 62: 967–971.

  • Chen PL, Scully P, Shew JY, Wang JY, Lee WH . (1989). Cell 58: 1193–1198.

  • Chen TT, Wang JY . (2000). Crit Rev Eukaryot Gene Exp 5: 79–95.

  • Chow KN, Dean DC . (1996). Mol Cell Biol 16: 4862–4868.

  • Choy KW, Pang CP, To KF, Yu CB, Ng JS, Lam DS . (2002). Invest Ophthalmol Vis Sci 43: 1344–1349.

  • Claudio PP, Howard CM, Baldi A, De Luca A, Fu Y, Condorelli G et al. (1994). Cancer Res 54: 5556–5560.

  • Claudio PP, Howard CM, Pacilio C, Cinti C, Romano G, Minimo C et al. (2000). Cancer Res 60: 372–382.

  • Claudio PP, Tonini T, Giordano A . (2002). Genome Biol 3: 3012.1–3012.9.

  • Cowell JK, Hogg A . (1992). Cancer Genet Cytogenet 64: 1–11.

  • Dahiya A, Gavin MR, Luo RX, Dean DC . (2000). Mol Cell Biol 20: 6799–6805.

  • D'Andrilli G, Masciullo V, Bagella L, Tonini T, Minimo C, Zannoni CF et al. (2004). Clin Cancer Res 10: 3098–3103.

  • De Caprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms H et al. (1989). Cell 58: 1085–1095.

  • De Falco G, Bellan C, Lazzi S, Claudio PP, La Sala D, Cinti C et al. (2003). Oncogene 22: 6214–6219.

  • De Sutter E, Havers W, Hopping W, Zeller G, Alberti W . (1987). Ophthalmic Paediatr Genet 8: 85–88.

  • Di Ciommo D, Gallie BL, Bremner R . (2000). Semin Cancer Biol 10: 255–269.

  • Durfee T, Mancini MA, Jones D, Elledge SJ, Lee WH . (1994). J Cell Biol 127: 609–622.

  • Dyson N . (1998). Genes Dev 12: 2245–2262.

  • Eng C, Li FP, Abramson DH, Ellsworth RM, Wong FL, Goldman MB et al. (1993). J Natl Cancer Inst 85: 1121–1128.

  • Ewen ME, Faha B, Harlow E, Livingston DM . (1992). Science 255: 85–87.

  • Ewen ME, Sluss HK, Sherr CJ, Matsuhime H, Kato J, Livingston DM . (1993). Cell 73: 487–497.

  • Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Albert DM et al. (1986). Nature 323: 643–646.

  • Fung YK, Murphree AL, T'Ang A, Qian J, Hinrichs SH, Benedict WF . (1987). Science 236: 1657–1661.

  • Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B . (1989). Hum Genet 83: 155–158.

  • Hall JG . (1988). Am J Hum Genet 43: 355–363.

  • Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC . (1999). Cell 98: 859–869.

  • Horsthemke B . (1992). Cancer Genet Cytogenet 63: 1–7.

  • Huang Q, Choy KW, Cheung KF, Fu WL, Pang CP . (2003). Mol Vis 9: 502–507.

  • Imbert I, Coignet LJA, Pellestor F . (2001). Cancer Genet Cytogenet 128: 141–147.

  • Kadonaga JT . (1998). Cell 92: 307–313.

  • Kaelin A . (1955). Arch Julius Klaus-Stift 30: 442–485.

  • Kato J, Matsuhijme H, Hiebert SW, Ewen ME, Sherr CJ . (1993). Genes Dev 7: 331–342.

  • Klutz M, Horsthemke B, Lohmann D . (1999). Am J Hum Genet 64: 667–668.

  • Knudson AG . (1971). Proc Natl Acad Sci USA 68: 820–823.

  • Knudson AG, Strong LC, Anderson DE . (1973). Prog Med Genet 9: 113–158.

  • Kouzarides T . (1995). Semin Cancer Biol 6: 91–98.

  • Kusnetsova LE, Prigogina EL, Pogosianz HE, Belkina BM . (1982). Hum Genet 61: 201–204.

  • Lacy S, Whyte P . (1997). Oncogene 14: 2395–2406.

  • Lai A, Lee JM, Yang WM, De Caprio JA, Kaelin Jr WG, Seto E et al. (1999). Mol Cell Biol 19: 6632–6641.

  • Lazzi S, Bellan C, De Falco G, Cinti C, Ferrari F, Nyongo A et al. (2002). Hum Pathol 33: 723–731.

  • Lee JO, Russo AA, Pavletich NP . (1998). Nature 391: 859–865.

  • Lee WH, Bookstein R, hong F, Young LJ, Shew JY, Lee EY . (1987a). Science 235: 1394–1399.

  • Lee WH, Murphree AL, Benedict WF . (1984). Nature 309: 458–460.

  • Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ et al. (1987b). Nature 329: 642–645.

  • Lohmann DR . (1999). Hum Mutat 14: 283–288.

  • Lohmann DR, Gallie BL . (2004). Am J Med Genet Part C (Semin Med Genet) 129C: 23–28.

  • Lohmann DR, Gerick M, Brandt B, Oelschlager U, Lorenz B, Passarge E et al. (1997). Am J Hum Genet 61: 282–294.

  • Ludlow JW, Shon J, Pipas JM, Livingston DM, De Caprio JA . (1990). Cell 60: 387–396.

  • Luo RX, Postigo AA, Dean DC . (1998). Cell 92: 463–473.

  • Macaluso M, Cinti C, Russo G, Russo A, Giordano A . (2003). Oncogene 22: 3511–3517.

  • Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP et al. (1998). Nature 391: 601–605.

  • Meloni AR, Smith EJ, Nevins JR . (1999). Proc Natl Acad Sci USA 96: 9574–9579.

  • Mihara K, Cao XR, Yen A, Chandler S, Driscoll B, Murphree AL et al. (1989). Science 246: 1300–1303.

  • Murphree AL, Benedict WF . (1985). Science 223: 1028–1033.

  • Mutti L, De Luca A, Claudio PP, Convertino G, Carbone M, Giordano A . (1998). Dev Biol Stand 94: 47–53.

  • Nevins JR . (1998). Cell Growth Differ 9: 585–593.

  • Ohtani-Fujita N, Dryja TP, Rapaport JM, Fujita T, Matsumura S, Ozasa K et al. (1997). Cancer Genet Cytogenet 98: 43–49.

  • Oliveros O, Yunis E . (1995). Cancer Genet Cytogenet 82: 155–160.

  • Onadim A, Hogg A, Baird PN, Cowell JK . (1992). Proc Natl Acad Sci USA 89: 6177–6181.

  • Pogosianz HE, Kuznetsova LE . (1986). Arch Geschwulstforsch 56: 135–143.

  • Qian Y, Luckey C, Horton L, Esser M, Templeton DJ . (1992). Mol Cell Biol 12: 5363–5372.

  • Qian YW, Lee EY . (1995). J Biol Chem 270: 25507–25513.

  • Ross JF, Liu X, Dynlacht BD . (1999). Mol Cell 3: 195–205.

  • Sakai T, Ohtani N, McGee TL, Robbins PD, Dryja TP . (1991). Nature 353: 83–86.

  • Sampieri K, Hadjistilianou T, Mari F, speciale C, Mencerelli MA, Cetta F et al. (2005). J Hum Genet 51: 209–216.

  • Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ et al. (1998). Genes Dev 12: 95–106.

  • Shen WJ, Kim HS, Tsai SY . (1995). J Biol Chem 270: 20525–20529.

  • Sherr CJ . (1996). Science 274: 1672–1677.

  • Shimuzu T, Toguchida J, Kato MV, Kaneko A, Ishizaki K, Sasaki MS . (1994). Am J Hum Genet 54: 793–800.

  • Sivakumaran TA, Ghose S, Kumar H, Singha U, Kucheria K . (1997). Acta Genet Med Gemellol 46: 193–198.

  • Squire J, Phillips RA, Boyce S, Godbout R, Rogers B, Gallie BL . (1984). Hum Genet 66: 46–53.

  • Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM . (1998). Mol Cell Biol 18: 2748–2757.

  • Sterner JM, Murata Y, Kim HG, Kennet SB, Templeton DJ, Horowitz JM . (1995). J Biol Chem 270: 9281–9288.

  • Sterner JM, Tao Y, Kennet SB, Kim HG, Horowitz JM . (1996). Cell Growth Differ 7: 53–64.

  • Strobeck MW, Knuden KE, Fribourg AF, De Cristofaro MF, Weissman BE, Imbalzano AN et al. (2000). Proc Natl Acad Sci USA 97: 7748–7753.

  • Suckling RD, Fitzgerald PH, Stewart J, Wells E . (1982). Br J Cancer 46: 729–736.

  • Toguchida J, McGee TL, Paterson JC, Eagle JR, Tucjer S, Yandell DW et al. (1993). Genomics 17: 535–543.

  • Tosi GM, Trimarchi C, Macaluso M, La Sala D, Ciccodicola A, Lazzi S et al. (2005). Oncogene 24: 5827–5836.

  • Trouche D, Le Chalony C, Muchardt C, Yaniv M, Kouzarides T . (1997). Proc Natl Acad Sci USA 94: 11268–11273.

  • Turleau C, de Grouchy J, Chavin-Colin F, Sunien C, Seger J, Schlienger P et al. (1995). Cancer Genet Cytogenet 16: 321–334.

  • Vogel F . (1954). Z menschl Vererb- u Konstitutionslehre 32: 308–336.

  • Weintraub SJ, Chow KNB, Luo RX, Zhang SH, He S, Dean DC . (1995). Nature 375: 812–815.

  • Whitaker LL, Su H, Baskaran R, Knudsen ES, Wang JY . (1998). Mol Cell Biol 18: 4032–4042.

  • Zeschnigk M, Schmitz B, Dittrich B, Buiting K, Horsthemke B, Doerfler W . (1997). Hum Mol Genet 6: 387–395.

  • Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX et al. (2000). Cell 101: 79–89.

  • Zheng L, Flesken-Nikitin A, Chen PL, Lee WH . (2002). Cancer Res 62: 2498–2502.

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Acknowledgements

We thank Katia Sampieri for critical comments on this paper and Emma Thorley for manuscript revision.

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  1. Department of Human Pathology and Oncology, University of Siena, Siena, Italy

    G De Falco & A Giordano

  2. Sbarro Institute for Cancer Research and Molecular Medicine, College of Science & Technology Temple University, Philadelphia, 19122, PA, USA

    G De Falco & A Giordano

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Correspondence to A Giordano.

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De Falco, G., Giordano, A. pRb2/p130: a new candidate for retinoblastoma tumor formation. Oncogene 25, 5333–5340 (2006). https://doi.org/10.1038/sj.onc.1209614

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