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Regulation of cellular senescence by Rb2/p130

Oncogene volume 25, pages 5257–5262 (2006)Cite this article

Abstract

Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.

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Acknowledgements

This work was supported by a grant from Deutsche Krebshilfe (Grant 10-1975). The Heinrich-Pette-Institute is financially supported by Freie und Hansestadt Hamburg and Bundesministerium für Gesundheit.

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  1. Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Martinistr, Hamburg, Germany

    H Helmbold, W Deppert & W Bohn

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Correspondence to W Bohn.

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Helmbold, H., Deppert, W. & Bohn, W. Regulation of cellular senescence by Rb2/p130. Oncogene 25, 5257–5262 (2006). https://doi.org/10.1038/sj.onc.1209613

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